Spying the neutralizing epitopes on E2 N-terminal by candidate epitope-vaccines against classical swine fever virus

Vaccine
Xiao-Nan Dong, Ying-Hua Chen

Abstract

Our previous study proved that the N-terminal (aa693-711) of glycoprotein E2 contained sequential neutralizing epitopes. In this study, four candidate epitope-vaccines (EVs) were separately prepared and evaluated. Among them, epitope-vaccine EV-BC1a (BC1a: aa693-699) induced high level of epitope-specific neutralizing antibodies and exhibited similar protective capability with that induced by Chinese vaccine strain (C-strain). These results confirmed CKEDYRY (aa693-699) as a principal sequential neutralizing epitope on E2 N-terminal. Moreover, these findings also indicate that epitope-vaccine is a potent candidate strategy for marker vaccine against classical swine fever virus (CSFV).

Citations

Jan 24, 2007·Vaccine·Martin BeerKlaus Depner
Sep 3, 2010·Journal of Peptide Science : an Official Publication of the European Peptide Society·Marta MonsóDavid Andreu
Aug 29, 2006·Vaccine·Xiao-Nan Dong, Ying-Hua Chen
Nov 26, 2013·Veterinary Immunology and Immunopathology·Hong TianXiangtao Liu

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