PMID: 6978877Feb 1, 1982Paper

SQ 26,180, a novel monobactam. I Taxonomy, fermentation and biological properties

The Journal of Antibiotics
J S WellsR B Sykes

Abstract

Strains of Chromobacterium violaceum, isolated from various environments, were found to produce a novel monocyclic beta-lactam antibiotic. The antibiotic, SQ 26,180 was weakly active against Gram-positive and Gram-negative bacteria with the exception of mutants hypersensitive to beta-lactam antibiotics. The compound was highly stable to beta-lactamases and acted as an inhibitor of the P99 enzyme from Enterobacter cloacae. SQ 26,180 showed affinity for penicillin-binding proteins 1a, 4 and 5/6 of Escherichia coli and inhibited R61 DD-carboxypeptidases.

Citations

Nov 9, 2012·Natural Product Reports·Refaat B HamedChristopher J Schofield
Mar 5, 2016·Genome Announcements·Xiaofei WangJosephine R Chandler
Jul 22, 2019·Applied and Environmental Microbiology·Saida BenomarJosephine R Chandler
Dec 1, 2010·Applied and Environmental Microbiology·Dirk BlomLaure Weisskopf
Mar 28, 2013·The Journal of Antibiotics·Kapil Tahlan, Susan E Jensen
Jan 25, 2018·Journal of Natural Products·Janusz J PetkowskiSara Seager

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