SQ house dust mite (HDM) SLIT-tablet provides clinical improvement in HDM-induced allergic rhinitis

Expert Review of Clinical Immunology
Ludger KlimekPascal Demoly

Abstract

House dust mite (HDM) allergy represents a highly prevalent inhalant allergy, and exposure to HDM allergens results in allergic rhinitis with persistent symptoms that may not be adequately controlled with available allergy pharmacotherapy. Allergy immunotherapy constitutes a complementary treatment option targeting the underlying immunological mechanisms of allergic disease and represents the only treatment with a potential for disease modification and long-term efficacy. As traditional allergy immunotherapy delivered by subcutaneous injection of specific HDM allergens involves a time-consuming treatment regimen and a risk of systemic adverse reactions, sublingually administered allergy immunotherapy (SLIT) has been investigated as a more convenient treatment option with similar levels of efficacy and an improved safety profile that allows for at-home daily administration. In this Drug Profile, we provide a review of the clinical data behind the SQ HDM SLIT-tablet, which was recently approved for the treatment of HDM-induced allergic rhinitis by regulatory authorities in Europe and Japan.

References

Oct 1, 1982·The Journal of Allergy and Clinical Immunology·G J GleichJ W Yunginger
Jan 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R Van ReeR C Aalberse
Jun 13, 1998·The Journal of Pharmacy and Pharmacology·H Seager
Jun 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·D MunganL Gürbüz
Aug 13, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·V A VarneyA J Frew
Oct 14, 2003·International Archives of Allergy and Immunology·Sabine Flicker, Rudolf Valenta
Jul 9, 2004·Current Opinion in Allergy and Clinical Immunology·Petra A Wachholz, Stephen R Durham
Nov 2, 2004·The European Respiratory Journal·V Bauchau, S R Durham
Sep 7, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Giorgio CiprandiAndrea Vizzaccaro
Oct 6, 2005·International Archives of Allergy and Immunology·Marcello BagnascoGiovanni Passalacqua
Aug 26, 2006·Allergy·E Alvarez-CuestaUNKNOWN EAACI, Immunotherapy Task Force
Jan 10, 2009·The Journal of Allergy and Clinical Immunology·Albrecht BufeFriedrich Kaiser
Jun 2, 2009·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Guy Scadding, Stephen Durham
Sep 8, 2010·The Journal of Allergy and Clinical Immunology·Jan L BrozekUNKNOWN Grading of Recommendations Assessment, Development and Evaluation Working Group
Oct 23, 2010·The Journal of Allergy and Clinical Immunology·Moisés A CalderónPascal Demoly
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Cezmi A Akdis, Mübeccel Akdis
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Michael BlaissDavid P Skoner
Jan 8, 2011·The Journal of Allergy and Clinical Immunology·Harold S NelsonDavid I Bernstein
Mar 30, 2011·Allergy·S RadulovicStephen Durham
Jun 28, 2011·Allergy·N Novak, J-P Allam
Jun 21, 2011·Acta Pharmaceutica : a Quarterly Journal of Croatian Pharmaceutical Society and Slovenian Pharmaceutical Society, Dealing with All Branches of Pharmacy and Allied Sciences·Bhatu P Badgujar, Atish S Mundada
Oct 12, 2011·Current Opinion in Allergy and Clinical Immunology·Aarif O EifanStephen R Durham
Aug 8, 2012·The Journal of Allergy and Clinical Immunology·Daphne Koinis-MitchellRobert B Klein
Nov 1, 2009·The World Allergy Organization Journal·G Walter CanonicaTorsten Zuberbier
Apr 6, 2013·The Journal of Allergy and Clinical Immunology·Janine DretzkeCatherine Meads
Apr 16, 2013·Current Allergy and Asthma Reports·Vivek D GandhiHarissios Vliagoftis
Apr 30, 2013·The Journal of Allergy and Clinical Immunology·Peter S CreticosHendrik Nolte
May 28, 2013·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hendrik NolteJennifer Maloney
Jan 7, 2014·The Journal of Allergy and Clinical Immunology·Karl-Christian BergmannRobert K Zeldin
Jan 29, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jennifer MaloneyHendrik Nolte
Apr 1, 2014·The World Allergy Organization Journal·Giorgio Walter CanonicaOsman Yusuf
May 20, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hendrik NolteJennifer Maloney
Sep 19, 2014·Current Opinion in Allergy and Clinical Immunology·Jean-Pierre Allam, Natalija Novak

❮ Previous
Next ❯

Citations

Jun 21, 2016·Expert Review of Clinical Immunology·Giorgio Walter CanonicaHolger Mosbech
Oct 21, 2016·Expert Review of Clinical Immunology·Pascal DemolyKarl-Christian Bergmann
Feb 1, 2017·Expert Opinion on Investigational Drugs·Peter A RickettiThomas B Casale
May 22, 2018·International Forum of Allergy & Rhinology·Jie YangShiyu Liao
May 22, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Montserrat Alvaro-LozanoMarta Vazquez-Ortiz
Apr 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Rainer ReiberEike Wüstenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Related Papers

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
Liang ZhuLei Cheng
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
Junjie DingBin Chen
Clinical Reviews in Allergy & Immunology
J BousquetF B Michel
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A BozekJ Jarzab
© 2022 Meta ULC. All rights reserved