SQSTM1 and Paget's disease of bone

Calcified Tissue International
Robert Layfield, L Hocking

Abstract

Mutations in the Sequestosome 1 gene ( SQSTM1; also known as p62) have recently been identified as the cause of 5q35-linked Paget's disease of bone (PDB). All of the mutations identified to date affect the ubiquitin-associated (UBA) domain of SQSTM1, a region of the protein that binds noncovalently to ubiquitin. In this review we consider the possible functional significance of the SQSTM1-ubiquitin interaction, and consequences of the SQSTM1 UBA domain mutations. Clarification of the in vivo roles of SQSTM1 in bone-cell function will be central to improving our understanding of the molecular pathogenesis of PDB and related conditions.

References

Sep 1, 1983·Journal of Epidemiology and Community Health·J A SofaerA E Emery
Jan 1, 1981·Metabolic Bone Disease & Related Research·D J Barker
Apr 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A A Morales-PigaG López-Abente
Jul 21, 1995·The Journal of Biological Chemistry·E S JohnsonA Varshavsky
Mar 1, 1995·Molecular and Cellular Biology·J SpenceD Finley
Feb 1, 1994·Human Molecular Genetics·A E HughesR A Mollan
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·I JoungJ Shin
Jul 1, 1996·Trends in Biochemical Sciences·M Rechsteiner, S W Rogers
Jan 1, 1996·Trends in Biochemical Sciences·C P PontingS J Winder
Nov 1, 1996·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E S Siris
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·A PulsS Stabel
Oct 6, 1997·The EMBO Journal·J M Galan, R Haguenauer-Tsapis
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·J SchultzC P Ponting
Jun 17, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S I HaslamS H Ralston
Oct 6, 1998·Annual Review of Biochemistry·A Hershko, A Ciechanover
Dec 30, 1998·Archives of Pharmacal Research·J Shin
Feb 18, 1999·Molecular and Cellular Biology·M J LallenaJ Moscat
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·H HsuW J Boyle
Jul 28, 1999·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·A NaitoJ Inoue
Jan 5, 2000·The EMBO Journal·J S ThrowerC M Pickart
Jun 16, 2000·The Journal of Biological Chemistry·F MiaoT R O'Connor
Jun 22, 2000·American Journal of Medical Genetics·M A NanceM C Speer
Jul 25, 2000·Seminars in Cell & Developmental Biology·K D Wilkinson
Dec 29, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H HelfrichS H Ralston
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D GoodJ T Shaw
Apr 27, 2001·Nature Structural Biology·B L BertolaetS I Reed

❮ Previous
Next ❯

Citations

May 1, 2012·Calcified Tissue International·Stuart H Ralston, Rob Layfield
Aug 29, 2006·Journal of Bone and Mineral Metabolism·Shinjiro TakataHideki Yoshikawa
Jul 16, 2008·Lancet·Stuart H RalstonIan R Reid
Aug 26, 2006·Nature Clinical Practice. Rheumatology·Anna Daroszewska, Stuart H Ralston
Mar 28, 2013·DNA and Cell Biology·Xiaolong LinZuo Wang
Apr 3, 2008·The Journal of Clinical Investigation·Wei JinShao-Cong Sun
Dec 6, 2007·BMC Biochemistry·Robert Layfield, Barry Shaw
Mar 19, 2014·American Journal of Otolaryngology·Kenichi TakanoTetsuo Himi
May 23, 2014·BMJ Case Reports·Dukhabandhu NaikThomas Vizhalil Paul
Mar 8, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L Corral-GudinoJ del Pino-Montes
Feb 22, 2012·Expert Opinion on Pharmacotherapy·Ian R Reid
Jan 11, 2012·Reumatología clinica·Leticia Lojo Oliveira, Antonio Torrijos Eslava
Oct 1, 2011·Seminars in Arthritis and Rheumatism·Pui Yan Jenny Chung, Wim Van Hul
Feb 17, 2009·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jesús TorresGonzalo Hernández
Dec 17, 2008·Free Radical Biology & Medicine·Yifeng DuMarie W Wooten
Mar 15, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·James R CaveyRobert Layfield
Jul 4, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sarah L ReaThomas Ratajczak
Mar 29, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Greet BeyensWim Van Hul
Nov 30, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dorit NaotIan R Reid
Feb 9, 2008·American Journal of Medical Genetics. Part a·Virginia E KimonisGiles D J Watts
Oct 3, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gavin Ja LucasStuart H Ralston
Dec 22, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mark J BollandTim Cundy
Oct 27, 2007·Neuropathology and Applied Neurobiology·E KuusistoI Alafuzoff
Jan 19, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Luigi GennariRanuccio Nuti
Dec 17, 2011·Annals of the New York Academy of Sciences·Stuart H Ralston, Omar M E Albagha
Aug 10, 2011·Orvosi hetilap·Judit Donáth, Gyula Poór
Nov 21, 2015·BoneKEy Reports·Omar Me Albagha
Sep 12, 2014·Arquivos brasileiros de endocrinologia e metabologia·Luiz GrizUNKNOWN Brazilian Society of Endocrinology and Metabolism
Oct 2, 2007·Expert Reviews in Molecular Medicine·Robert Layfield
Jan 21, 2020·Medical Teacher·Celso P PagatpatanJeff Daniel C Lauron
Nov 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Brya G MatthewsIan R Reid
Oct 21, 2006·Biochemical Society Transactions·R LayfieldM S Searle
Sep 27, 2020·Calcified Tissue International·Judit DonáthGyula Poór
Sep 8, 2020·Internal Medicine·Takumi NakamuraMikio Shoji
Nov 1, 2009·Expert Review of Endocrinology & Metabolism·Brya Matthews, Tim Cundy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Alberto FalchettiMaria Luisa Brandi
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
L HockingS H Ralston
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Teresa L Johnson-PaisRobin J Leach
© 2021 Meta ULC. All rights reserved