Squalene epoxidase, located on chromosome 8q24.1, is upregulated in 8q+ breast cancer and indicates poor clinical outcome in stage I and II disease.

British Journal of Cancer
Mike W HelmsBurkhard Brandt

Abstract

Gains of chromosomes 7p and 8q are associated with poor prognosis among oestrogen receptor-positive (ER+) stage I/II breast cancer. To identify transcriptional changes associated with this breast cancer subtype, we applied suppression subtractive hybridisation method to analyse differentially expressed genes among six breast tumours with and without chromosomal 7p and 8q gains. Identified mRNAs were validated by real-time RT-PCR in tissue samples obtained from 186 patients with stage I/II breast cancer. Advanced statistical methods were applied to identify associations of mRNA expression with distant metastasis-free survival (DMFS). mRNA expression of the key enzyme of cholesterol biosynthesis, squalene epoxidase (SQLE, chromosomal location 8q24.1), was associated with ER+ 7p+/8q+ breast cancer. Distant metastasis-free survival in stage I/II breast cancer cases was significantly inversely related to SQLE mRNA in multivariate Cox analysis (P<0.001) in two independent patient cohorts of 160 patients each. The clinically favourable group associated with a low SQLE mRNA expression could be further divided by mRNA expression levels of the oestrogen-regulated zinc transporter LIV-1. The data strongly support that SQLE mRNA expression...Continue Reading

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Citations

Oct 12, 2010·BMC Cancer·Fabrice SircoulombMax Chaffanet
Feb 2, 2013·PloS One·Hiu-Fung YuenWanJin Hong
Jul 5, 2012·Biology Direct·Shinuk KimCharles DeLisi
Jun 26, 2015·Breast Cancer Research and Treatment·Monica D'ArcyMelissa A Troester
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May 4, 2020·Progress in Lipid Research·Ngee Kiat ChuaAndrew J Brown
Jul 28, 2020·Advanced Drug Delivery Reviews·Lisa M ButlerJohannes V Swinnen

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Methods Mentioned

BETA
PCR
dissection
chromosomal aberrations

Software Mentioned

R
R Core
gcrma
Blast search
Affymetrix
Primer Express

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