Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Zhenghui SuiPenhua Lu

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies with a poor response to chemotherapy. It is very important to identify novel therapeutic targets. Squalene epoxidase (SQLE), one of the rate-limiting enzymes in the cholesterol biosynthesis, recently has been found to be involved in the tumorigenesis. However, its expression profile and function in the progression of HCC remain largely unknown. Here, we found that the expression of SQLE was upregulated in the HCC tissues. Moreover, overexpression of SQLE in HCC cells promoted cell proliferation and migration, while downregulation of SQLE inhibited the tumorigenicity of HCC cells in vitro and in vivo. Mechanistically, SQLE positively regulated the ERK signaling. Taken together, our study suggests that SQLE is a promising therapeutic target in HCC.

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Citations

Apr 3, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Wei DengQingyi Wei
May 20, 2016·Cancer Research·Omer F KuzuGavin P Robertson
Jan 17, 2021·Journal of Fungi·Alia A Sagatova
May 4, 2020·Progress in Lipid Research·Ngee Kiat ChuaAndrew J Brown
Jul 23, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Huanji XuFeng Bi
Jul 28, 2020·Advanced Drug Delivery Reviews·Lisa M ButlerJohannes V Swinnen
Jul 28, 2020·Cancer Letters·Sara FeltrinGabriele Zoppoli
Apr 3, 2021·Frontiers in Cell and Developmental Biology·Ming TangDerek J Richard
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Rosa VonaPaola Matarrese
Jun 11, 2021·Frontiers in Oncology·Isabella GiacominiVeronica Cocetta
Jun 19, 2021·Frontiers in Oncology·Alyssa S ZembroskiDorothy Teegarden
Oct 28, 2021·Analytical Chemistry·Tienan ZangXiaoling Zhang

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