Squamoid Eccrine Ductal Carcinoma: A Clinicopathologic Study of 30 Cases

The American Journal of Surgical Pathology
Michiel P J van der HorstThomas Brenn

Abstract

Squamoid eccrine ductal carcinoma is a poorly documented skin adnexal carcinoma showing squamous and duct differentiation. It is regarded to be of low-grade malignant potential, but limited follow-up information is available. To study their clinical behavior and histologic features, 30 squamoid eccrine ductal carcinomas were identified from departmental and referral files. Hematoxylin and eosin-stained sections were reviewed, and immunohistochemistry for carcinoembryonic antigen and epithelial membrane antigen was examined to confirm duct differentiation. Clinical follow-up was obtained from patient records and referring pathologists. The tumors presented as nodules or plaques (median size, 1.0 cm; range, 0.5 to 2.5 cm) with a predilection for the head and neck (77%). The patients were elderly (median age, 79.5 y; range, 10 to 96 y) with a male predominance. Histologically, these poorly demarcated tumors were characterized by an infiltrative growth pattern within the dermis and additional invasion of subcutis in 70%. Median tumor thickness was 4.3 mm (range, 1.5 to 18 mm). Superficially, the tumors resembled well-differentiated squamous cell carcinoma. In the deeper reaches, they were organized in cords and strands showing duct...Continue Reading

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Citations

Jul 7, 2018·The American Journal of Dermatopathology·Sterling S MckissackNathanial R Miletta
Sep 29, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas Brenn
Nov 30, 2018·Anais Brasileiros De Dermatologia·Márcio Martins Lobo-JardimNeusa Yurico Sakai Valente
Jul 31, 2019·Clinical Case Reports·Sunmin YimWon-Serk Kim
Aug 3, 2017·Journal of Cutaneous Pathology·Gauri PanseChristine J Ko
Jan 1, 2018·Anais Brasileiros De Dermatologia·Márcio Martins Lobo-JardimNeusa Yurico Sakai Valente
Mar 23, 2021·Journal of Cutaneous Pathology·Pavandeep GillPriyadharsini Nagarajan
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Jun 12, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Peter ChowBenjamin F Kelley

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Methods Mentioned

BETA
biopsy
biopsies

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