Squamous and Neuroendocrine Specific Immunohistochemical Markers in Head and Neck Squamous Cell Carcinoma: A Tissue Microarray Study

Head and Neck Pathology
James S LewisJustin A Bishop

Abstract

The performance characteristics of neuroendocrine-specific and squamous-specific immunohistochemical markers in head and neck squamous cell carcinomas (SCC), in particular in oropharyngeal tumors in this era of human papillomavirus (HPV)-induced cases, are not well-established. The differential diagnosis for poorly differentiated SCCs, for nonkeratinizing oropharyngeal SCCs, and for other specific SCC variants such as basaloid SCC and undifferentiated (or lymphoepithelial-like) carcinomas includes neuroendocrine carcinomas. Given that neuroendocrine carcinomas of the head and neck are aggressive regardless of HPV status, separating them from SCC is critically important. In this study, we examined the neuroendocrine markers CD56, synaptophysin, and chromogranin-A along with the squamous markers p40 and cytokeratin 5/6 in a large tissue microarray cohort of oral, oropharyngeal, laryngeal, and hypopharyngeal SCCs with known HPV results by RNA in situ hybridization for the oropharyngeal tumors. Results were stratified by site and specific SCC variant. The neuroendocrine stains were rarely expressed in SCC (<1% overall) with CD56 the least, and chromogranin-A the most, specific markers. Further, p40 and cytokeratin 5/6 were very con...Continue Reading

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Citations

Mar 21, 2018·Head and Neck Pathology·William H Westra
Nov 24, 2018·Cancer Cytopathology·Derek B AllisonSyed Z Ali
Aug 16, 2019·American Journal of Clinical Pathology·Carolina StrosbergJuan C Hernandez-Prera
Jun 28, 2020·Journal of Cutaneous Pathology·Caroline E TalsmaMay P Chan
Mar 1, 2021·American Journal of Otolaryngology·Margaret B MitchellYoung Kim
Jul 12, 2020·Journal of the American Society of Cytopathology : JASC·Doreen Palsgrove, Justin A Bishop
May 15, 2021·Annals of Diagnostic Pathology·Sepideh MadahianJacob R Bledsoe

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