Squamous-cell carcinoma in mature cystic teratoma of the ovary: systematic review and analysis of published data

The Lancet Oncology
Andreas HackethalKarsten Münstedt

Abstract

Up to a quarter of ovarian masses originate from germ cells, and many of these are mature cystic teratomas. The secondary development of malignancy is a rare but well-known phenomenon in patients with ovarian teratomas. Squamous-cell carcinoma accounts for 80% of secondary malignant transformations of ovarian teratomas. We aimed to do an up-to-date systematic review of this rare malignant transformation. 64 suitable studies provided information on 277 patients. Squamous-cell carcinoma in mature cystic teratoma was mainly found in women aged more than 50 years, with high concentrations of squamous-cell-carcinoma antigen and cancer antigen CA125, and with ovarian tumours more than 100 mm in size. Patients with FIGO stage Ia tumours had better survival than those with more advanced disease. Complete resection together with hysterectomy, bilateral salpingo-oophorectomy and lymphadenectomy for patients with advanced disease, followed by adjuvant chemotherapy with an alkylating drug was associated with higher survival, radiotherapy was not. We make proposals for investigation and treatment of this rare disorder.

References

Aug 1, 1988·International Journal of Oral and Maxillofacial Surgery·N BradleyY Anavi
Jul 1, 1983·British Journal of Obstetrics and Gynaecology·G W Stamp, E M McConnell
Nov 1, 1994·Obstetrics and Gynecology·W H Parker, J S Berek
Sep 1, 1995·Pathology International·T FujiiK Saito
Dec 1, 1996·Gynecologic Oncology·C J TsengC C Pao
Nov 7, 1999·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·H IsodaF Kayama
Oct 21, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J L BenedetS Pecorelli
Feb 13, 2001·Acta Obstetricia Et Gynecologica Scandinavica·R J ChenC Y Hsieh
Jun 12, 2003·Gynecologic Oncology·John L PowellMichael Mattison
Aug 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S TangjitgamolS Jesadapatarakul
Nov 14, 2003·Gynecologic and Obstetric Investigation·B CaspiZ Appelman
Feb 10, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J Mechery, O Adeyemi
Nov 20, 2004·Archives of Gynecology and Obstetrics·Pei-Fang LaiChun Yu
Mar 12, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Thomas M Ulbright
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Diane StirlingMary E Porteous
Oct 8, 2005·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Masayuki Takemori, Ryuichiro Nishimura
Oct 20, 2005·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·V KaranjgaokarD R Poole
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S-Y RimH-S Choi
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·M DedeA Haşimi
Mar 10, 2006·Archives of Gynecology and Obstetrics·P SangheraJ Simon
Mar 21, 2006·Journal of the American Academy of Dermatology·Lana H Hawayek, Diya F Mutasim
Mar 3, 2007·Archives of Gynecology and Obstetrics·J VergutsI Vergote

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Citations

Nov 10, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·H SevestreW Al Thakfi
Nov 10, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·H Marret, M Cayrol
Nov 12, 2013·Journal de gynécologie, obstétrique et biologie de la reproduction·N Bourdel, M Canis
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ReedUNKNOWN ESMO Guidelines Working Group
Mar 25, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·An-Jen ChiangNelson N H Teng
Oct 1, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Giovanna GiordanoSfefano Raboni
Jul 27, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Eleonora Savitchi, Sumati Rao
Sep 9, 2010·Ultrasound Quarterly·Deborah LevineUNKNOWN Society of Radiologists in Ultrasound
Oct 12, 2011·World Journal of Gastroenterology : WJG·Hoi Man Deon ChongChak Man Jimmy Li
Dec 2, 2011·Archives of Pathology & Laboratory Medicine·Etienne Mahe, Monalisa Sur
Jul 11, 2013·Case Reports in Obstetrics and Gynecology·Gülşah BalıkEmine Seda Güvendağ Güven
Jun 6, 2014·Case Reports in Obstetrics and Gynecology·Kazuhiro NishiokaKiyoshige Horie
Mar 29, 2014·Endocrine Pathology·Laura A Adamson-SmallJacqueline A Hobbs
Oct 26, 2014·Current Oncology Reports·Patricia Roxburgh, Rosalind Glasspool
Dec 30, 2014·Journal of Mid-life Health·Ranu Patni
Feb 19, 2016·The Journal of Obstetrics and Gynaecology Research·Kosuke YoshidaFumitaka Kikkawa
Jul 3, 2015·Oncology Letters·Zeynep TosunerRamazan Dansuk
Feb 13, 2016·Gynecologic Oncology·Dimitrios NasioudisSteven S Witkin
Apr 7, 2012·La Presse médicale·Houssine BoufettalNaïma Samouh
Sep 19, 2015·Taiwanese Journal of Obstetrics & Gynecology·Hui-Yu ChuangEing-Mei Tsai
Nov 3, 2015·Taiwanese Journal of Obstetrics & Gynecology·An-Jen ChiangTsung-Hsien Chang
Oct 20, 2010·Journal of Minimally Invasive Gynecology·Camran NezhatMichael Lewis
Oct 19, 2010·Annals of Diagnostic Pathology·Mariah R BaughnNoel Weidner
May 25, 2016·Indian Journal of Surgical Oncology·Saniya SharmaLakhbir Kaur Dhaliwal
Mar 4, 2011·Pediatric Blood & Cancer·M Chabaud-WilliamsonF Auber
Nov 15, 2011·Diagnostic Cytopathology·David W Mensi
Mar 28, 2012·The Journal of Obstetrics and Gynaecology Research·Yumiko ItoFumitaka Kikkawa
Mar 28, 2012·The Journal of Obstetrics and Gynaecology Research·Volkan UlkerOvgu Aydin
Nov 19, 2010·The Journal of Obstetrics and Gynaecology Research·Korhan KahramanFeride Söylemez
Jan 30, 2014·Journal of Magnetic Resonance Imaging : JMRI·Sung Bin Park, Jong Beum Lee
Jan 16, 2013·Case Reports in Obstetrics and Gynecology·Suna AvcıFatih Borlu
May 10, 2012·The Journal of Obstetrics and Gynaecology Research·Taeko KataokaHiroshi Hoshiai
Mar 26, 2011·Journal of Ovarian Research·Fatima A ZakkouriHassan Errihani
Feb 16, 2015·International Journal of Clinical Oncology·Takanori YokoyamaYosifumi Sugawara
Jun 10, 2014·American Journal of Obstetrics and Gynecology·Monica C PasternakAileen Gariepy
Oct 1, 2009·Journal of Medical Imaging and Radiation Oncology·S ChoudharyC Marginean
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Hai-Li ZhuHong Shen
Mar 17, 2015·Annals of Diagnostic Pathology·Mohamed Mokhtar DesoukiAmal Kanbour-Shakir
Feb 25, 2014·Fertility and Sterility·Guillaume LegendrePhilippe Descamps
Jun 7, 2014·Frontiers in Oncology·Naoki MatsumotoMasato Nagino
Oct 20, 2012·Case Reports in Pathology·Shramana Mandal, Bhawana A Badhe
Jun 23, 2016·Gynecologic Oncology Reports·Lorna A BrudieSarfraz Ahmad
May 29, 2016·Cancer Epidemiology·Marina T van LeeuwenClaire M Vajdic

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