Squamous cell carcinoma of the anal canal: utilization and outcomes of recommended treatment in the United States

Annals of Surgical Oncology
Karl Y BilimoriaAmy Halverson

Abstract

Over the past two decades, recommended treatment for squamous cell carcinoma of the anal canal has shifted from surgery to primary chemoradiation. Resection is now reserved for persistent or recurrent disease. Our objectives were (1) to evaluate treatment trends over the past 20 years, (2) to assess contemporary treatment utilization, and (3) to examine the impact of recommended vs nonguideline treatment on survival. From the National Cancer Data Base (1985-2005), 38,882 patients with anal canal cancer were identified. Regression models were used to assess factors associated with use of nonguideline treatment (vs chemoradiation +/-surgery). Univariate and multivariate methods were used to assess the impact of treatment on survival. From 1985 to 2005, the use of chemoradiation increased significantly with a concomitant decrease in treatment with surgery alone (P < .0001). However, only 74.9% (5014 of 6696) of patients underwent primary chemoradiation therapy in 2003-2005. Overall, 22.7% (1523 of 6696) of patients received treatment that was not concordant with established guidelines: primary surgery (13.0%) and primary chemotherapy or radiation (9.7%). Patients were significantly less likely to receive guideline treatment if mal...Continue Reading

References

Oct 1, 1976·Annals of Surgery·O H Beahrs, S M Wilson
Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·B J CummingsC N Catton
May 1, 1974·Diseases of the Colon and Rectum·N D NigroB Considine
Nov 1, 1982·Diseases of the Colon and Rectum·B J CummingsW D Rider
Aug 15, 1997·Cancer·R J MyersonH R Menck
Mar 16, 2000·The New England Journal of Medicine·D P RyanR J Mayer
Jun 27, 2003·The New England Journal of Medicine·Elizabeth A McGlynnEve A Kerr
Oct 8, 2003·Annals of Internal Medicine·Mitchell L MargolisJohn Hansen-Flaschen
Dec 30, 2003·Journal of Surgical Oncology·David P WinchesterR Scott Jones
Feb 11, 2004·Archives of Surgery·Arden M MorrisLaura-Mae Baldwin
Jun 5, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Mats TalbäckMåns Rosén
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Per J NilssonBengt Glimelius
Jul 26, 2005·Journal of the National Comprehensive Cancer Network : JNCCN·Paul F EngstromUNKNOWN National Comprehensive Cancer Network
Sep 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dawn HershmanAlfred I Neugut
Nov 11, 2005·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Elizabeth Y ChiaoDeborah Schrag
Aug 15, 2006·International Journal of Radiation Oncology, Biology, Physics·Scott Edelman, Peter A S Johnstone
Aug 22, 2006·American Journal of Surgery·Mohamad A EloubeidiSelwyn M Vickers
Oct 26, 2006·JAMA : the Journal of the American Medical Association·Jerome H LiuClifford Y Ko
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Apr 17, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kaye M Reid-LombardoUNKNOWN Gastric Patient Care Evaluation Group from the Commission on Cancer
Oct 12, 2007·The New England Journal of Medicine·Rita Mangione-SmithElizabeth A McGlynn
Jan 10, 2008·Annals of Surgical Oncology·Karl Y BilimoriaClifford Y Ko
Jan 29, 2008·Journal of the American College of Surgeons·Karl Y BilimoriaClifford Y Ko
Jul 23, 2008·Archives of Surgery·Karl Y BilimoriaDavid J Bentrem
Oct 18, 2008·Journal of the American College of Surgeons·Karl Y BilimoriaDavid J Bentrem

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Citations

May 31, 2012·Sexually Transmitted Infections·E Lynne ConwayJane Adams
Jun 19, 2012·Diseases of the Colon and Rectum·Scott R SteeleUNKNOWN Standards Practice Task Force of the American Society of Colon and Rectal Surgeons
May 16, 2017·Digestive Diseases and Sciences·Emily F MiduraIan M Paquette
Dec 23, 2017·International Journal of Colorectal Disease·Kunal SuradkarRavi P Kiran
Sep 25, 2019·Journal of Surgical Oncology·Adam C FieldsNelya Melnitchouk
Apr 21, 2009·Expert Review of Anticancer Therapy·Nicolas C BuchsPascal Gervaz
Aug 18, 2020·American Journal of Clinical Oncology·Suleyman Y GoksuNina N Sanford

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