Squamous cell carcinoma of the head and neck in solid organ transplant recipients

Head & Neck
Diego A PreciadoGeorge L Adams

Abstract

The increased incidence of cancer after solid organ transplantation is well established in the literature, yet outcome studies in this population are rare. Excluding skin cancers, squamous cell carcinomas make up most head and neck cancers in transplant recipients. At our institution, of 5300 solid organ transplant recipients, 34 have had head and neck cancer develop. We reviewed the records of the 23 recipients whose cancer was treated here. Only 6 of the 23 recipients were alive at the time of our chart review. Of these, three had already survived 5 years. The 10 recipients diagnosed early (stage I or II) had significantly longer survival after cancer diagnosis than the 13 diagnosed at an advanced stage (stage III or IV) (96.0 mo vs 9.0 mo, p <.001). In all, 14 (60.8%) of the 23 recipients died of cancer within 2 years after diagnosis, 12 (50.2%) within 12 months. The sum of the daily doses of immunosuppressive drugs at cancer diagnosis was significantly greater for recipients who died within 2 years (p =.02). Furthermore, the difference in average doses of both prednisone (p =.001) and azathioprine (p =.028) was also significantly greater for those who died within 2 years. The average dose of cyclosporine was also greater, b...Continue Reading

References

Sep 11, 1991·Head & Neck·B W TaylorR R Million
Dec 20, 1990·The New England Journal of Medicine·I Penn
Mar 1, 1990·The Journal of Dermatologic Surgery and Oncology·S M DinehartS V Pollack
Jan 1, 1988·Annual Review of Medicine·I Penn
Jan 1, 1970·Archives of Surgery·I PennT E Starzl
Jun 27, 1995·Transplantation·S B GayaP D Mason
Aug 1, 1993·Archives of Dermatology·G J HruzaK A Arndt
Nov 1, 1996·Baillière's Clinical Rheumatology·W W Gibbon
Sep 1, 1996·Clinical Nurse Specialist CNS·J Young-Mason
Sep 4, 1998·Journal of Transplant Coordination : Official Publication of the North American Transplant Coordinators Organization (NATCO)·M P Flattery
Mar 20, 1999·Transplantation Proceedings·A G Sheil
Jan 11, 2000·Transplantation·E Danpanich, B L Kasiske

❮ Previous
Next ❯

Citations

Apr 11, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·James GuggenheimerDebra J Stock
May 29, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·Christine G Gourin, David J Terris
Jul 9, 2008·Acta Oto-laryngologica·Antti A MäkitieEero Pukkala
Mar 28, 2008·Acta otorrinolaringológica española·Xavier LeónMiquel Quer
Oct 16, 2004·The Journal of Investigative Dermatology·John A Carucci
Jul 19, 2003·The Australasian Journal of Dermatology·Michael Veness, Shawn Richards
Aug 28, 2009·Clinical Transplantation·Lee L LanzaWilliam D Irish
May 22, 2008·Journal of Surgical Oncology·Snehal G Patel, William M Lydiatt
Jan 13, 2006·The Australasian Journal of Dermatology·Michael J Veness
Mar 2, 2010·Head & Neck·Robert P TakesAlfio Ferlito
Apr 28, 2011·Veterinary Ophthalmology·Jennifer DreyfusRichard R Dubielzig
Sep 23, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D CantarovichUNKNOWN FRANCIA Study Trial Investigators Group
Apr 5, 2013·Head & Neck·Naomi RabinovicsGideon Bachar
Aug 19, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Sabine RoithmaierMax A Schwarz
Jun 20, 2006·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Federico L AmpilDavid D Kim
Jul 13, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·João MassanoArtur Ferreira
Oct 2, 2014·Veterinary Ophthalmology·Taryn L OvertonElizabeth M Whitley
Mar 11, 2015·Oral Oncology·Naomi RabinovicsAron Popovtzer
Dec 3, 2003·Seminars in Cutaneous Medicine and Surgery·John A Carucci
Jun 29, 2018·Clinical and Experimental Dermatology·C J PuzaP J Mosca
May 26, 2012·The Journal of Craniofacial Surgery·Luiz Carlos Ferreira da SilvaThiago de Santana Santos
Nov 24, 2012·Seminars in Cutaneous Medicine and Surgery·Melissa Pulitzer
Aug 21, 2020·Head & Neck·Catriona M DouglasJonathan C Irish
Feb 14, 2019·Inflammatory Bowel Diseases·Loes H C NissenUNKNOWN IBD/HNC group
Sep 29, 2019·Inflammatory Bowel Diseases·Steffi E M van de VenL H C Nissen
Jun 21, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Isabel Fernández-Carrera GonzálezJavier Gavilanes-Plasencia
Aug 18, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Sarah Nicole HamiltonRobert Olson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.