Squamous cell carcinoma of the larynx with osteosarcoma-like stromal metaplasia

Acta Oto-laryngologica
Gino MarioniAlberto Staffieri

Abstract

Osseous or chondroid metaplasias are uncommonly found adjacent to laryngeal squamous cell carcinoma (SCC). These findings are less unusual in the spindle cell variant. We describe a moderately differentiated laryngeal SCC associated with osteocartilaginous metaplasia of the adjacent stroma which exhibited very similar morphologic changes and mitoses to an osteosarcoma. These uncommon findings can be more clearly understood if they are viewed as changes determined by the microenvironment of the tumour-host interface, as indicated in recent studies. Tumour cells seem able to regulate stromal development and differentiation via the release of growth factors and the induction of growth factor receptor expression on the cell surface. Irrespective of the limited number of reported cases, the association of SCCs of the larynx with osteocartilaginous metaplasia does not seem to support the adoption of treatments of choice that differ in approach to those for site- and stage-matched SCCs without osteocartilaginous metaplasia.

References

Jan 1, 1992·The Journal of Laryngology and Otology·J KlijanienkoB Luboinski
Apr 1, 1986·The Journal of Laryngology and Otology·M D CreminT Tun
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·L D Thompson
Dec 31, 1997·Journal of Clinical Gastroenterology·H NakajimaS Yagihashi
Mar 21, 1998·The American Journal of Surgical Pathology·C ChhiengP P Rosen
Nov 14, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·X WangK Kennichi
Jan 29, 2002·The American Journal of Surgical Pathology·Lester D R ThompsonDennis K Heffner
Feb 14, 2002·Annals of Diagnostic Pathology·Fernando Martinez MadrigalMario A Luna
Dec 21, 2002·Differentiation; Research in Biological Diversity·Gerald R Cunha, Lynn M Matrisian
Dec 21, 2002·Differentiation; Research in Biological Diversity·Margareta M Mueller, Norbert E Fusenig
Jan 28, 2003·The American Journal of Pathology·Ole William PetersenLone Rønnov-Jessen
Mar 11, 2003·Acta Oto-laryngologica·Gino MarioniGiuseppe Altavilla

❮ Previous
Next ❯

Citations

Jul 3, 1979·Biochimica Et Biophysica Acta·B A Baird, G G Hammes
Apr 29, 2005·American Journal of Otolaryngology·Gino MarioniAlberto Staffieri
Sep 2, 2016·The Laryngoscope·Renee L EigstiHenry T Hoffman
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Bruce M Wenig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
P J SlootwegH Lubsen
Breast Cancer : the Journal of the Japanese Breast Cancer Society
Yuko KijimaTakashi Aikou
© 2021 Meta ULC. All rights reserved