Squamous cell carcinoma of the pancreas: A systematic review and pooled survival analysis

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Ioannis Ntanasis-StathopoulosTheodoros N Sergentanis

Abstract

The diagnosis and treatment of squamous cell carcinoma of the pancreas pose dilemmas in the clinical practice. The present study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Eligible articles were sought in MEDLINE up to 30th April 2016. A pooled Cox regression analysis was performed to evaluate factors potentially associated with overall survival (OS) and relapse-free survival (RFS). Fifty-four cases of pure squamous cell pancreatic carcinomas were identified in total. The mean age was 61.9 years, and most patients were males (61.1%). The median OS was 7 months. Resectability (p = 0.003) and more recent publication year (p < 0.001) were associated with better OS, as was low/intermediate tumour grade (p = 0.032) with RFS. Despite its poor prognosis, survival rates of pancreatic squamous cell carcinoma seem improved during the recent years; resectability and low/intermediate grade emerged as favourable prognostic factors. Collaborative epidemiological studies are deemed necessary to further validate the results stemming from the published case reports of this rare entity.

Citations

Nov 6, 2018·Cancer Biology & Therapy·Ahsan WahabOrimisan Samuel Adekolujo
Aug 14, 2019·Diagnostic Cytopathology·Guy I SydneyIlias Nikas
Feb 2, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Courtney J PokrzywaAlexander V Fisher
Sep 4, 2020·World Journal of Gastrointestinal Oncology·Monica NigerMaria Di Bartolomeo
Nov 13, 2021·Frontiers in Surgery·Danling GuoHongjie Hu

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