Squamous cell carcinoma of the tongue complicating chronic oral mucosal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

American Journal of Hematology
Ching H SzetoYok L Kwong

Abstract

Two patients underwent allogeneic hematopoietic stem cell transplantation (HSCT) for acute myeloid leukemia. Chronic graft-versus-host disease (GVHD) developed, with persistent symptomatic oral lesions. At 2 and 6 years post-HSCT, both patients developed squamous cell carcinoma (SCC) of the tongue in areas previously involved by chronic GVHD. None had any known risk factor for SCC. Histologically, moderate to severe dysplasia was present in noncancerous oral mucosa. Oral SCC is rarely described after HSCT, and a review of the reported cases showed chronic GVHD to be a common risk, suggesting that the chronic inflammation associated with GVHD might be of pathogenetic significance.

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Citations

Jun 8, 2006·Bone Marrow Transplantation·M CavalierR P Nelson
Jan 22, 2013·American Journal of Otolaryngology·Ameer T ShahRichard O Wein
Mar 17, 2012·Journal of the American Academy of Dermatology·Sharon R HymesEdward W Cowen
Dec 18, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·June-Ho ByunJeong-Hee Lee
Jan 31, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Ibtisam Al-HashimiIsaäc van der Waal
Feb 16, 2007·The British Journal of Dermatology·J-C FricainA Taïeb
Jan 6, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Majid EbrahimiKarin Nylander
May 16, 2012·Head & Neck·Joseph Chun-Kit ChungWilliam Ignace Wei
Nov 26, 2020·Bone Marrow Transplantation·Stella SantaronePaolo Di Bartolomeo

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