Squamous cell carcinomas of the anterior oral cavity are commonly associated with simplex (or differentiated) oral intraepithelial neoplasia: clinical and pathologic significance

International Journal of Surgical Pathology
Aleksandra Paliga, Kien T Mai

Abstract

We investigated the occurrence of differentiated oral intraepithelial neoplasia (DOIN) that met the criteria for differentiated intravulvar neoplasia, associated with invasive squamous cell carcinoma (SCC) of the anterior oral cavity, and its clinicopathologic significance. Sixty-nine consecutive cases of SCC of the anterior oral cavity were categorized into 2 groups: group A comprised SCC associated with DOIN; Group B consisted of cases associated with classical SCC in situ. Fifty-five cases (80%) were classified as group A, or DOIN lesions, with only 14 (20%) as group B. All cases were associated with invasive SCC, except 2 cases in group B. Squamous epithelium continuous or adjacent to invasive SCC displayed consistent changes in the parabasal and basal layers with (1) cytologic atypia with proliferation of parabasal cells in downward expansion causing reactive proliferation of the basal cell layer in early stage and invading the basal layer in late stage, (2) disordered nuclear/cytoplasmic arrangement, and (3) a "cobblestone" appearance characterized by prominent intercellular spaces and cytoplasmic density involving the entire cell (dyskeratosis) of the parabasal layer. p53 and Ki67 immunostaining revealed linear reactivit...Continue Reading

References

Aug 1, 1991·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·F ChangK Syrjänen
Aug 1, 1989·The American Journal of Surgical Pathology·C A RubioH Z Zhao
Aug 1, 1995·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·L M AbbeyM Cushing
Apr 1, 1993·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A G Ostör
Nov 1, 2002·The American Journal of Surgical Pathology·Rüdiger KlaesMagnus von Knebel Doeberitz
Jan 15, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Dena J FischerStephen M Schwartz
Nov 28, 2007·Annual Review of Pathology·Ignacio I Wistuba, Adi F Gazdar
Dec 25, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Nicholas J Mulvany, David G Allen
Feb 7, 2008·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S WarnakulasuriyaE Dabelsteen
Apr 3, 2008·Mayo Clinic Proceedings·Shanthi Marur, Arlene A Forastiere
Jul 22, 2008·The Lancet Oncology·Michel P ColemanUNKNOWN CONCORD Working Group
Sep 18, 2008·International Journal of Cancer. Journal International Du Cancer·Brigiet M HoevenaarsJohan Bulten
Aug 22, 2009·Journal of Public Health Dentistry·Gabriela Fürst VaccarezzaPedro Michaluart-Júnior
Jan 12, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alvaro P PintoChristopher P Crum
Oct 12, 2010·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Preeti SharmaPooja Aggarwal
Jan 8, 2011·International Journal of Clinical Oncology·Teruo Amagasa
Jan 15, 2011·International Journal of Clinical Oncology·Toshiyuki Izumo
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayDonald Maxwell Parkin
Mar 9, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sagar C PatelBhishamjit S Chera
Mar 15, 2011·The American Journal of Surgical Pathology·Alcides ChauxAntonio L Cubilla
Nov 30, 2012·Histopathology·Marta Del PinoJaume Ordi
Feb 2, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Loes C G van den EindenJohan Bulten

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Citations

Mar 1, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·M T Fernández-FiguerasA Ariza
Sep 7, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Kien T Mai
Apr 20, 2018·Experimental Dermatology·Andrey A Panteleyev
Mar 9, 2021·Expert Review of Molecular Diagnostics·Kenneth P H PritzkerDavid Mock
Oct 4, 2021·Oral Diseases·Ilkay EvrenJan G A M de Visscher

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Methods Mentioned

BETA
biopsies
SISA

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