Squamous metaplasia in the healing of chronic colonic ulcers of the rat

The Journal of Pathology
D R Reeve

Abstract

Chronic ulcers of the rat colon were produced by a administering a 3 per cent. hydrogen peroxide enema. Twenty-three per cent. of the animals with chronic ulcers had areas of squamous metaplasia at the wound margins which in some cases covered the defect. Electron microscopy revealed some areas similar to epidermis with the four characteristic cell layers. The cells demonstrated many filaments, membrane-coated granules, keratohyalin granules and keratin. The cells were linked by complex of cytoplasmic bridges and frequent desmosomes. Basal cells often displayed large irregular nuclei with double nucleoli. Other areas demonstrated a grossly irregular surface with marked cellular pleomorphism and defects in the basement lamina. The incidence of squamous metaplasia and squamous-cell carcinoma in the colon of man is discussed. The ultrastructural characteristics of squamous metaplasia in the trachea and bronchi is recorded and compared with those of the colon. It is suggested that as neoplasia has been observed to follow experimental metaplastic lesions in the bronchus, a similar ocurrence could take place in the colon as the squamous cells exhibited similar characteristics.

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Citations

Dec 1, 1985·Diseases of the Colon and Rectum·R Lafreniere, A S Ketcham
Mar 3, 1998·Journal of Pediatric Gastroenterology and Nutrition·P BollenY Vandenplas
Mar 30, 2016·World Journal of Gastrointestinal Surgery·Glen R GuerraSamuel Y Ngan
Feb 1, 1980·Journal of Morphology·K A Brackett, S F Townsend
Apr 18, 2017·Molecular and Clinical Oncology·Shufen ZhaoWensheng Qiu
Sep 1, 1992·International Journal of Colorectal Disease·T A SchneiderA M Vernava

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