Squaric acid derivatives as VLA-4 integrin antagonists

Bioorganic & Medicinal Chemistry Letters
John R PorterBarry Langham

Abstract

SAR studies aimed at improving the rate of clearance by the incorporation of a 3,4-diamino-3-cyclobutene-1,2-dione group as an amino acid isostere in a series of VLA-4 integrin antagonists are described.

Citations

May 29, 2002·Bioorganic & Medicinal Chemistry Letters·R P AlexanderG Higgs
Mar 6, 2003·Bioorganic & Medicinal Chemistry Letters·John R PorterGraham J Warrellow
May 17, 2003·Bioorganic & Medicinal Chemistry Letters·George A DohertyWilliam K Hagmann
Oct 14, 2003·Bioorganic & Medicinal Chemistry Letters·Marcin StasiakMaher Qabar
Mar 19, 2011·Journal of Medicinal Chemistry·Nicholas A Meanwell
Apr 22, 2011·Chemical Biology & Drug Design·Sundarapandian ThangapandianKeun Woo Lee
Mar 21, 2003·Medicinal Research Reviews·Ginger X Yang, William K Hagmann
Sep 16, 2020·Chemical Reviews·Kylie A Agnew-Francis, Craig M Williams
May 21, 2005·The Journal of Organic Chemistry·Guido VerniestNorbert De Kimpe

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