SR-A-Targeted Phase-Transition Nanoparticles for the Detection and Treatment of Atherosclerotic Vulnerable Plaques

ACS Applied Materials & Interfaces
Man YeDajing Guo

Abstract

Atherosclerosis is a major cause of sudden death and myocardial infarction, instigated by unstable plaques. Thus, the early detection of unstable plaques and corresponding treatment can improve the prognosis and reduce mortality. In this study, we describe a protocol for the preparation of nanoparticles (NPs) combined with the phase transitional material perfluorohexane (PFH) and with dextran sulfate (DS) targeting class A scavenger receptors (SR-A) for the diagnosis and treatment of atherosclerotic vulnerable plaques. The results showed that the Fe-PFH-poly(lactic- co-glycolic acid) (PLGA)/chitosan (CS)-DS NPs were fabricated successfully, with the ability to undergo phase transition by low-intensity focused ultrasound (LIFU) irradiation to achieve ultrasound imaging; a high carrier rate of Fe3O4 had a good negative enhancement effect on magnetic resonance imaging (MRI). The NPs had a high binding affinity for activated macrophages and could be endocytosed by the macrophages and notably induced apoptosis under LIFU irradiation by an acoustic droplet vaporization effect in vitro. Furthermore, in an ex vivo atherosclerotic plaque model of apolipoprotein E knockout (KO) (apoE-/-) mice induced by high cholesterol, the NPs selectiv...Continue Reading

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Citations

Apr 29, 2020·International Journal of Molecular Sciences·Nataliya V MushenkovaAlexander N Orekhov
Jan 12, 2021·Advanced Drug Delivery Reviews·Jun ChenHo-Wook Jun
Mar 9, 2021·Frontiers in Physiology·Manman LiLiming Yang
Nov 14, 2020·Cells·Gary A CuthbertShervanthi Homer-Vanniasinkam
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bianca Elena-Beatrice CrețuVera Balan
Oct 2, 2021·Bioconjugate Chemistry·Juan GuoHuiyu Liu

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