SR calcium handling dysfunction, stress-response signaling pathways, and atrial fibrillation

Frontiers in Physiology
Xun Ai

Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia. It is associated with a markedly increased risk of premature death due to embolic stroke and also complicates co-existing cardiovascular diseases such as heart failure. The prevalence of AF increases dramatically with age, and aging has been shown to be an independent risk of AF. Due to an aging population in the world, a growing body of AF patients are suffering a diminished quality of life and causing an associated economic burden. However, effective pharmacologic treatments and prevention strategies are lacking due to a poor understanding of the molecular and electrophysiologic mechanisms of AF in the failing and/or aged heart. Recent studies suggest that altered atrial calcium handling contributes to the onset and maintenance of AF. Here we review the role of stress-response kinases and calcium handling dysfunction in AF genesis in the aged and failing heart.

References

Jun 1, 1992·Cell Calcium·H SchulmanT Meyer
May 1, 1990·Journal of Structural Biology·M S ForbesS I Purdy-Ramos
Jan 1, 1969·Pflügers Archiv : European journal of physiology·O RougierE Coraboeuf
May 1, 1995·The American Journal of Physiology·J W BassaniD M Bers
Mar 16, 1994·JAMA : the Journal of the American Medical Association·E J BenjaminP A Wolf
Feb 1, 1997·European Heart Journal·M R CowieD E Grobbee
Oct 23, 1997·Circulation·B M PsatyP M Rautaharju
Mar 25, 1998·Journal of Cardiovascular Electrophysiology·C TimmermansH J Wellens
Apr 30, 1998·Physiological Reviews·K B Beckman, B N Ames
Jul 8, 1998·Journal of Cardiovascular Electrophysiology·H M van der VeldenH J Jongsma
Mar 27, 1999·Cardiology Clinics·P J Podrid
Sep 4, 1999·Circulation Research·D R Van WagonerJ M Nerbonne
Jul 27, 2000·Cardiovascular Research·H M van der VeldenH J Jongsma
Aug 12, 2000·European Journal of Heart Failure·A B LinnéB Israelsson
Aug 19, 2000·Circulation Research·D M Bers
Feb 24, 2001·Pflügers Archiv : European journal of physiology·N S FreestoneR Vetter
Mar 10, 2001·Recent Progress in Hormone Research·J AvruchX F Zhang
Aug 31, 2001·Journal of the American College of Cardiology·L PolontchoukS Dhein
Jun 14, 2002·Cardiovascular Research·Sawa KostinJutta Schaper
Sep 7, 2002·Heart Failure Reviews·Vias Markides, Nicholas S Peters
Sep 18, 2002·Journal of Molecular and Cellular Cardiology·Jaime DeSantiagoDonald M Bers
Dec 21, 2002·Basic Research in Cardiology·Jin-Long HuangShih-Ann Chen
Apr 16, 2003·Journal of Cardiovascular Electrophysiology·Hakan OralFred Morady
Jun 14, 2003·Circulation Research·Fabien Brette, Clive Orchard

❮ Previous
Next ❯

Citations

Jun 4, 2019·Acta Physiologica·Wan-Li ChengYi-Jen Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass
enzymatic dissociation

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.

Related Papers

Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation
H E HeemstraH J Crijns
European Journal of Cardiovascular Nursing : Journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology
Carina CarnlöfBjöörn Fossum
© 2022 Meta ULC. All rights reserved