Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson's Disease Models

Frontiers in Neuroscience
Hanyu YangDan Zhang

Abstract

Chronic neuroinflammation is of great importance in the pathogenesis of Parkinson's disease (PD). During the process of neuroinflammation, overactivated microglia release many proinflammatory factors, which eventually induce neurodegeneration. Inhibition of excessive microglial activation is regarded as a promising strategy for PD treatment. Src is a non-receptor tyrosine kinase that is closely related to tumors. Recently, some reports indicated that Src is a central mediator in multiple signaling pathways including neuroinflammation. The aim of our study was to demonstrate the role of Src in microglial regulation and neuroinflammation. The lipopolysaccharide (LPS)-stimulated BV2 microglia model and the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD model were applied in this study. The results showed that inhibition of Src could significantly relieve microgliosis and decrease levels of inflammatory factors. Besides, inhibition of Src function reduced the loss of dopaminergic neurons and improved the motor behavior of the MPTP-treated mice. Thus, this study not only verified the critical role of Src tyrosine kinase in neuroinflammation but also further proved that interfering neuroinflammation is beneficial for ...Continue Reading

References

Jan 1, 1997·Annual Review of Cell and Developmental Biology·S M Thomas, J S Brugge
Apr 15, 1999·Annual Review of Neuroscience·F González-Scarano, G Baltuch
Jun 29, 2004·Molecular Immunology·Clifford A Lowell
Aug 18, 2004·International Immunopharmacology·Iwona Kurkowska-JastrzebskaAnna Członkowska
Sep 24, 2004·Cancer Cell·Rumey Ishizawar, Sarah J Parsons
Oct 22, 2005·Annals of Neurology·Honglei ChenAlberto Ascherio
May 17, 2007·Current Medicinal Chemistry·S Thameem DheenEng-Ang Ling
Oct 21, 2009·Anaesthesia·I A Iselin-ChavesG L Savoldelli
Oct 21, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ashley S HarmsMalú G Tansey
Mar 4, 2011·Neurology·Xiang GaoAlberto Ascherio
Jul 22, 2011·Journal of Signal Transduction·Banibrata Sen, Faye M Johnson
Dec 3, 2011·Neurobiology of Aging·Gunjan DhawanColin K Combs
Nov 10, 2012·International Journal of Biological Sciences·Masato Okada
Dec 18, 2013·Immunology·Sandra AmorJohannes M van Noort
Jan 30, 2014·Frontiers in Physiology·Sandy T LiuAndrzej Ptasznik
Dec 17, 2014·Acta Neuropathologica Communications·Rosa Giráldez-PérezAmelia Sánchez-Capelo
Feb 11, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Roskoski
Jul 2, 2015·Pharmacology & Therapeutics·Yutaka Nakagawa, Kenji Chiba
Apr 25, 2016·Progress in Neurobiology·Valerie JoersAnna R Carta
Jul 13, 2016·Journal of Neurochemistry·Sigurlaug Sveinbjornsdottir
Dec 18, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rosa CalvelloDario Domenico Lofrumento
May 10, 2017·Journal of Neuroinflammation·Kelly S KirkleyRonald B Tjalkens
Jul 18, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiao-Feng LiJin Ding
Sep 10, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Eun-Joo ShinHyoung-Chun Kim

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Datasets Mentioned

BETA
ABI7900

Methods Mentioned

BETA
transgenic
confocal microscopy
nuclear translocation

Software Mentioned

ImageJ
GraphPad Prism
Statistical Package for

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