Src Kinase Dependent Rapid Non-genomic Modulation of Hippocampal Spinogenesis Induced by Androgen and Estrogen

Frontiers in Neuroscience
Mika SomaSuguru Kawato

Abstract

Dendritic spine is a small membranous protrusion from a neuron's dendrite that typically receives input from an axon terminal at the synapse. Memories are stored in synapses which consist of spines and presynapses. Rapid modulations of dendritic spines induced by hippocampal sex steroids, including dihydrotestosterone (DHT), testosterone (T), and estradiol (E2), are essential for synaptic plasticity. Molecular mechanisms underlying the rapid non-genomic modulation through synaptic receptors of androgen (AR) and estrogen (ER) as well as its downstream kinase signaling, however, have not been well understood. We investigated the possible involvement of Src tyrosine kinase in rapid changes of dendritic spines in response to androgen and estrogen, including DHT, T, and E2, using hippocampal slices from adult male rats. We found that the treatments with DHT (10 nM), T (10 nM), and E2 (1 nM) increased the total density of spines by ~1.22 to 1.26-fold within 2 h using super resolution confocal imaging of Lucifer Yellow-injected CA1 pyramidal neurons. We examined also morphological changes of spines in order to clarify differences between three sex steroids. From spine head diameter analysis, DHT increased middle- and large-head spines...Continue Reading

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Citations

Jul 2, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Adithya MohandassEleonora Zakharian
Sep 2, 2020·Journal of Neurovirology·Kristen A McLaurinCharles F Mactutus
Feb 20, 2019·Frontiers in Endocrinology·Dulce Carolina Rodríguez-LozanoIgnacio Camacho-Arroyo
Dec 18, 2019·Frontiers in Neuroendocrinology·C A FinneyM J Morris

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Methods Mentioned

BETA
confocal microscopy
myristoylation

Software Mentioned

AutoDeblur
Spiso
Neurolucida
3D

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