SRD5A3: A surprising role in glycosylation.

Cell
Ashlee R Stiles, David W Russell

Abstract

The steroid 5alpha-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.

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Citations

Dec 19, 2012·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Abdulmaged M Traish
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Jul 1, 2021·Journal of Neuroendocrinology·Silvia DiviccaroRoberto Cosimo Melcangi
Jul 29, 2021·Drug Testing and Analysis·Loredana IannellaXavier de la Torre

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