SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin.

The Journal of Biological Chemistry
B BerwinSalvatore V Pizzo

Abstract

Calreticulin and gp96 (GRP94) traffic associated peptides into the major histocompatibility complex class-I cross-presentation pathway of antigen-presenting cells (APCs). Efficient accession of the cross-presentation pathway requires APC receptor-mediated endocytosis of the chaperone/peptide complexes. Previously, scavenger receptor class-A (SRA) was shown to play a substantial role in trafficking gp96 and calreticulin into macrophages, accounting for half of total receptor-mediated uptake. However, the scavenger receptor ligand fucoidin competed the chaperone uptake beyond that accounted for by SRA, indicating that another scavenger receptor(s) may also contribute. Consistent with this hypothesis, we showed that the residual calreticulin uptake into SRA(-/-) macrophages is competed by the scavenger receptor ligand acetylated low density lipoprotein (LDL). We now report that an additional scavenger receptor, SREC-I (scavenger receptor expressed by endothelial cell-I), mediates the endocytosis of calreticulin and gp96. Ectopic expression of SREC-I in Chinese hamster ovary cells yielded chaperone recognition and uptake, and these processes were competed by the inhibitory ligands fucoidin and acetylated (Ac)LDL. Although AcLDL com...Continue Reading

References

May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P K SrivastavaL J Old
Oct 1, 1994·Current Opinion in Immunology·P K Srivastava, H Udono
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·H UdonoP K Srivastava
Oct 1, 1993·The Journal of Experimental Medicine·H Udono, P K Srivastava
Feb 1, 1996·Protein Expression and Purification·P A Wearsch, C V Nicchitta
Feb 12, 1998·The Journal of Biological Chemistry·H AdachiK Inoue
Dec 22, 1998·The Journal of Experimental Medicine·S E PikeG Tosato
May 13, 1999·Scandinavian Journal of Immunology·P Eggleton, D H Llewellyn
Nov 5, 1999·Nature Medicine·S GallucciP Matzinger
Dec 22, 1999·Seminars in Cell & Developmental Biology·Y Argon, B B Simen
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A KolE A Kurt-Jones
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K OhashiH Kolb
Mar 11, 2000·Immunology·S M TodrykR G Vile
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·R J BinderP K Srivastava
Mar 15, 2001·Nature Immunology·R J BinderP K Srivastava
Mar 30, 2001·The Journal of Biological Chemistry·B BerwinC V Nicchitta
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naveed N PanjwaniPramod K Srivastava
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Brent BerwinChristopher V Nicchitta
Oct 2, 2002·Immunity·Yves DelnestePascale Jeannin
Oct 16, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Qingbo Xu
Jan 9, 2003·European Journal of Immunology·Huguette BausingerDaniel Hanau

❮ Previous
Next ❯

Citations

Jan 16, 2009·Apoptosis : an International Journal on Programmed Cell Death·Oliver KeppGuido Kroemer
Feb 19, 2005·Current Oncology Reports·Pramod K Srivastava
May 10, 2008·Cell Death and Differentiation·T PanaretakisG Kroemer
Jul 31, 2013·Nature Immunology·Zaida G Ramirez-OrtizTerry K Means
Sep 29, 2011·The Cancer Journal·Dalil HannaniLaurence Zitvogel
Nov 28, 2007·Annual Review of Pathology·Kenneth L Rock, Hajime Kono
Jun 6, 2012·International Journal of Alzheimer's Disease·Kim Wilkinson, Joseph El Khoury
Mar 20, 2013·BioMed Research International·Elisa PanzariniLuciana Dini
Nov 20, 2008·Blood·Constança FigueiredoBritta Eiz-Vesper
Dec 30, 2008·Journal of Leukocyte Biology·Eyal AmielBrent Berwin
Jul 14, 2010·PLoS Neglected Tropical Diseases·Nandy C LópezArturo Ferreira
Jan 31, 2014·Marine Drugs·Jong-Young Kwak
Apr 21, 2011·Cellular and Molecular Life Sciences : CMLS·Amy R WyattMark R Wilson
Oct 27, 2007·Expert Opinion on Biological Therapy·Eckhard R Podack, Luis E Raez
May 15, 2007·FEBS Letters·Stuart K CalderwoodJimmy R Theriault
Mar 15, 2016·Frontiers in Immunology·Daming ZuoXiang-Yang Wang
Jan 14, 2010·Biochemical and Biophysical Research Communications·Yaling HuYong Xie
Dec 20, 2015·Immunological Reviews·Kristen K Penberthy, Kodi S Ravichandran
Jun 25, 2008·Current Opinion in Immunology·Antoine TesniereGuido Kroemer
Mar 15, 2015·Cytokine·Ayesha MurshidStuart K Calderwood
Mar 17, 2007·Experimental Cell Research·Eyal AmielBrent Berwin
Dec 2, 2006·Experimental Cell Research·Takayuki KuraishiYoshinobu Nakanishi
Nov 21, 2013·Immunologic Research·Natasa StrboEckhard R Podack
Apr 15, 2008·American Journal of Reproductive Immunology : AJRI·Natasa Strbo, Eckhard R Podack
Nov 6, 2007·Annals of the New York Academy of Sciences·Stuart K CalderwoodPhillip J Gray
Nov 6, 2007·Immunological Reviews·Michel ObeidGuido Kroemer
Oct 21, 2010·Annals of the New York Academy of Sciences·Isabelle MartinsGuido Kroemer
Sep 3, 2005·Immunological Investigations·John G FacciponteJohn R Subjeck
Jul 9, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Xiang-Yang Wang, John R Subjeck
Feb 4, 2011·Trends in Parasitology·Galia RamírezArturo Ferreira

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.