sRNA profiling in Aspergillus flavus reveals differentially expressed miRNA-like RNAs response to water activity and temperature

Fungal Genetics and Biology : FG & B
Youhuang BaiShihua Wang

Abstract

Small non-coding RNA (sRNA) in various organisms remains a mysterious subject. Although microRNAs (miRNAs) have been intensively investigated in plants and animals, the study of miRNAs in fungi has been limited. Only microRNA-like RNAs (milRNAs) have been reported in several filamentous fungi. In this study, Illumina deep sequencing was performed to characterize the sRNA in Aspergillus flavus and to evaluate their responses to water activity and temperature. Global expression analysis showed an extensively differential expression of sRNA loci in A. flavus under different temperature or water activities. In addition, a total of 135 milRNAs were identified in A. flavus. The milRNA profiles obtained in deep sequencing were further validated by RT-qPCR assay. The presence and differential expression of milRNAs under different temperature or water activities in A. flavus imply that milRNAs might play important roles in the mycotoxin biosynthesis and mycelium growth in fungi A. flavus.

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Citations

Jun 28, 2015·Fungal Genetics and Biology : FG & B·Chengshu WangKe-Qin Zhang
Jul 5, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Runmao LinAiping Zheng
Mar 5, 2016·Mycologia·José Manuel Villalobos-EscobedoNohemí Carreras-Villaseñor
Jan 29, 2017·Applied and Environmental Microbiology·Huimin MengBo Huang
Oct 6, 2017·FEMS Microbiology Reviews·Brice Felden, Luc Paillard
Jun 29, 2017·Annual Review of Microbiology·Santiago Torres-Martínez, Rosa M Ruiz-Vázquez
Mar 30, 2018·Food Safety·Jeffrey W CaryAna M Calvo
Jul 25, 2020·Functional & Integrative Genomics·Himanshu DubeyTilak Raj Sharma
Feb 19, 2019·Genetics and Molecular Biology·Juliana S de CurcioCélia Maria de Almeida Soares
Apr 16, 2018·Fungal Genetics and Biology : FG & B·Opemipo Esther FasoyinShihua Wang

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