SRRM4 gene expression correlates with neuroendocrine prostate cancer

The Prostate
Yinan LiXuesen Dong

Abstract

Neuroendocrine prostate cancer (NEPC) is an aggressive subtype of castrate-resistant prostate cancer characterized by poor patient outcome. Whole transcriptome sequencing analyses identified a NEPC-specific RNA splicing program that is predominantly controlled by the SRRM4 gene, suggesting that SRRM4 drives NEPC development. However, whether SRRM4 expression in patients may aid pathologists in diagnosing NEPC and predicting patient survival remains to be determined. In this study, we have applied RNA in situ hybridization and immunohistochemistry assays to measure the expressions of SRRM4, NEPC markers (SYP, CD56, and CHGA), and adenocarcinoma (AdPC) markers (AR, PSA) in a series of tissue microarrays constructed from castrate-resistant prostate tumors, treatment-naïve tumors collected from radical prostatectomy, and tumors treated with neoadjuvant hormonal therapy (NHT) for 0-12 months. Three pathologists also independently evaluated tumor histology and NEPC marker status. Here, we report that SRRM4 in castrate-resistant tumors is highly expressed in NEPC, strongly correlated with SYP, CD56, and CHGA expressions (Pearson correlation r = 0.883, 0.675, and 0.881; P < 0.0001) and negatively correlated with AR and PSA expressions ...Continue Reading

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Citations

Oct 24, 2019·Archives of Pathology & Laboratory Medicine·Jing HuJiaoti Huang
Jun 16, 2019·International Journal of Molecular Sciences·Simon J BaumgartBernard Haendler
Jul 8, 2020·The Journal of Clinical Investigation·Jessica LovnickiXuesen Dong
Jan 13, 2021·Current Oncology Reports·Yasutaka Yamada, Himisha Beltran
May 14, 2020·Neoplasia : an International Journal for Oncology Research·Daniel J ColemanJoshi J Alumkal

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