SRT1720 ameliorates sodium taurocholate-induced severe acute pancreatitis in rats by suppressing NF-κB signalling

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Chenyuan ShiYi Miao

Abstract

Severe acute pancreatitis (SAP) is a medical emergency that is often associated with multiple organ failure and high mortality. Although an SAP diagnosis requires prompt treatment, therapeutic options remain limited. SRT1720 is a newly formulatedSIRT1 activator that exerts multiple pharmacological activities with beneficial health effects. However, its potential as an SAP treatment has not been explored. The current study assessed the effect of SRT1720 on a rat model of sodium taurocholate-induced SAP and explored the underlying mechanism. SAP was induced in rats by retrograde injection of a 3.5% sodium taurocholate solution (1 ml/kg) in the biliopancreatic duct. SRT1720 (5 mg/kg) was administered intraperitoneally after sodium taurocholate exposure. Serum samples were analysed for inflammatory cytokine levels and select enzymatic activities using the enzyme-linked immunosorbent assay and commercial enzyme activity assay kits, respectively; protein expression levels were evaluated by western blotting; mRNA levels of biomarkers were determined by quantitative real-time PCR; histopathological changes were analysed by haematoxylin and eosin staining and immunohistochemistry.SRT1720 treatment significantly reduced serum amylase, li...Continue Reading

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Citations

Jun 12, 2019·International Journal of Molecular Sciences·Pedro Silva-VazJosé Guilherme Tralhão
Feb 6, 2020·Experimental and Therapeutic Medicine·Pingping FengHongbo Shen
Oct 30, 2020·Drug Delivery·Xue JiangLongfa Kou
Nov 18, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Walaa Yehia AbdelzaherMaha Yehia Kamel
Mar 9, 2021·Clinical Hemorheology and Microcirculation·Shanjun Zhao, Lei Yu

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