SRTX-d, a new native peptide of the endothelin/sarafotoxin family

FEBS Letters
A BdolahE Kochva

Abstract

The primary structure of a new sarafotoxin, SRTX-d, from the venom of Atractaspis engaddensis is described. SRTX-d differs from SRTX-b in two substitutions: Ile19 instead of Val and Thr2 instead of Ser. The toxicity of SRTX-d and its vasoconstriction potency are very low in comparison to SRTX-a and SRTX-b, whereas its IC50 for 125I-SRTX-b binding is similar to that of SRTX-b. It is suggested that the Thr to Ser substitution, which is shared by two additional weak members of the endothelin/sarafotoxin family, SRTX-c and ET-3, affects the biological activity of SRTX-d as well.

References

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Citations

May 30, 1991·European Journal of Pharmacology·Z WollbergE Kochva
Nov 9, 1993·European Journal of Pharmacology·P Schoeffter, A Randriantsoa
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