PMID: 11912443Mar 26, 2002Paper

SRY gene expression in the ovotestes of XX true hermaphrodites

The Journal of Urology
Joseph OrtenbergHerman Yee

Abstract

The pathogenesis of 46 XX true hermaphroditism is uncertain and the role of the SRY gene in ovotestis development has not been thoroughly evaluated. We ascertained the presence of the SRY gene and SRY protein in the ovotestis. We evaluated 8 ovotestes by cytogenetic analysis of fibroblast cell culture and analysis of gonadal tissue by polymerase chain reaction to detect the SRY gene and by immunohistochemistry with a monoclonal antibody to human recombinant SRY protein. Fibroblast culture of the ovotestes demonstrated a 46XX karyotype. By polymerase chain reaction all 8 ovotestes demonstrated the SRY gene at low levels. By immunohistochemistry SRY protein was detected in all ovotestes, predominantly in Sertoli and germ cells. The SRY gene has a role in ovotestis genesis. Mosaicism with a Y bearing cell line in the gonad is a possible explanation and further study is warranted.

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Citations

Sep 15, 2012·Journal of Medical Case Reports·Nelly Margarita Macías-GómezPatricio Barros-Núñez
Jan 25, 2011·International Journal of Urology : Official Journal of the Japanese Urological Association·Futoshi MatsuiMasahiro Nakayama
Jun 5, 2015·Clinics in Perinatology·Bonnie McCann-Crosby, V Reid Sutton
Jun 15, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Anna Biason-Lauber
Sep 21, 2004·American Journal of Medical Genetics. Part a·Karem NietoGloria Queipo
Feb 3, 2007·Cytogenetic and Genome Research·A RöpkeP F Wieacker

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