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SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis

Scientific Reports

Nov 4, 2016

Sergio Pulido-TamayoKathleen Marchal

Abstract

Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage. As a result, many cancer driver genes display mutual exclusivity across tumors. Ho...read more

Mentioned in this Paper

Econazole sulfosalicylate
Biochemical Pathway
Gene Expression Regulation, Neoplastic
Genome
Genes
Proto-Oncogenes
Neoplasms
Clone
Genomics
Analysis
7
24
Paper Details
References
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  • Citations2
1234
  • References40
  • Citations2

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SSA-ME Detection of cancer driver genes using mutual exclusivity by small subnetwork analysis

Scientific Reports

Nov 4, 2016

Sergio Pulido-TamayoKathleen Marchal

PMID: 27808240

DOI: 10.1038/srep36257

Abstract

Because of its clonal evolution a tumor rarely contains multiple genomic alterations in the same pathway as disrupting the pathway by one gene often is sufficient to confer the complete fitness advantage. As a result, many cancer driver genes display mutual exclusivity across tumors. Ho...read more

Mentioned in this Paper

Econazole sulfosalicylate
Biochemical Pathway
Gene Expression Regulation, Neoplastic
Genome
Genes
Proto-Oncogenes
Neoplasms
Clone
Genomics
Analysis
7
24

Similar Papers Found In These Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Structural Biology: Biophysics

Structural Biology: Biophysics describes the study of structural biology using various biophysical techiniques such as imaging, computational modeling, etc. Discover the latest research on structrual biology here.

Related Papers

Molecular BioSystems

Detection of driver pathways using mutated gene network in cancer

Molecular BioSystemsApril 28, 2016
Feng LiXiaofei Yang
Paper Details
References
  • References40
  • Citations2
1234
  • References40
  • Citations2
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