SSRI and SNRI withdrawal symptoms reported on an internet forum

The International Journal of Risk & Safety in Medicine
Tom StockmannJoanna Moncrieff

Abstract

Antidepressant withdrawal symptoms are well-recognised, but their potential duration remains uncertain. We aimed to describe the characteristics of withdrawal associated with two popular classes of antidepressants, including duration. We analysed the content of a sample of posts on an antidepressant withdrawal website. We compared the characteristics of withdrawal associated with SSRIs and SNRIs, including time of onset, duration and nature of symptoms. 110 posts about SSRI withdrawal, and 63 concerning SNRI withdrawal, were analysed. The mean duration of withdrawal symptoms was significantly longer with SSRIs than SNRIs: 90.5 weeks (standard deviation, SD, 150.0) and 50.8 weeks (SD 76.0) respectively; p = 0.043). Neurological symptoms, such as 'brain zaps,' were more common among SNRI users (p = 0.023). Psychosexual/genitourinary symptoms may be more common among SSRI users (p = 0.054). The website aims to help people with antidepressant withdrawal, and is therefore likely to attract people who have difficulties. Length of prior use of antidepressants was long, with a mean of 252.2 weeks (SD 250.8). People accessing antidepressant withdrawal websites report experiencing protracted withdrawal symptoms. There are some difference...Continue Reading

References

Feb 28, 2015·Psychotherapy and Psychosomatics·Giovanni A FavaEmanuela Offidani
Jul 1, 2014·The Lancet. Psychiatry·David J NuttStephen Lawrie
Nov 4, 2015·JAMA : the Journal of the American Medical Association·Elizabeth D KantorEdward L Giovannucci

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Citations

Aug 23, 2019·Epidemiology and Psychiatric Sciences·Michael P HengartnerJohn Read
Jan 7, 2020·The British Journal of Psychiatry : the Journal of Mental Science·Ivana Massabki, Elia Abi-Jaoude
Nov 9, 2019·Therapeutic Advances in Psychopharmacology·Tom Stockmann
May 22, 2019·BMJ : British Medical Journal·James DaviesAnne Guy
Jun 12, 2020·Therapeutic Advances in Psychopharmacology·Justin M Karter
Mar 24, 2021·Schizophrenia Bulletin·Mark Abie HorowitzDavid Taylor
May 19, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ai-Shan SuJing Zou
Apr 8, 2020·Psychotherapy and Psychosomatics·Fiammetta Cosci, Guy Chouinard

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