St John's wort (Hypericum perforatum) products - an assessment of their authenticity and quality

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Anthony BookerMichael Heinrich

Abstract

St John's wort products (Hypericum perforatum L.) are widely available for sale in many countries including the UK via the internet. In the UK, these products are required to hold either a marketing authorisation or Traditional herbal registration (THR) to be sold legally. The THR and other regulatory schemes help to ensure product safety and quality providing an example of best practice but there is a risk if both regulated and un-regulated products continue to be available to consumers. The project is embedded in a larger study aiming to investigate the quality of different herbal medicinal products along diverse value chains. Here we focus on a comparison of the quality of the finished products and assess phytochemical variation between registered products (THRs) and products obtained from the market without any registration. 47 commercial products (granulated powders and extracts) were sourced from different suppliers. We analysed these samples using high performance thin layer chromatography (HPTLC) and1H NMR spectroscopy coupled with multi-variate analysis software following a method previously developed by our group. The consistency of the products varies significantly. Adulteration of the products (36%), possibly with o...Continue Reading

Citations

Sep 27, 2019·Mini Reviews in Medicinal Chemistry·Mariangela MarrelliFilomena Conforti
Feb 12, 2019·Frontiers in Plant Science·Francesca ScottiMichael Heinrich
May 10, 2019·Frontiers in Pharmacology·Michael HeinrichKatja Löbel
May 25, 2020·Plant Foods for Human Nutrition·Nebojša KladarBiljana Božin
Aug 5, 2019·Journal of Ethnopharmacology·Geoffrey A Cordell
Jun 1, 2020·Current Pharmaceutical Design·Patricia Rocha de AraújoMarlus Chorilli
Feb 24, 2020·Phytochemistry·Konstantina ZeliouFotini N Lamari
May 4, 2021·Frontiers in Pharmacology·Mihael Cristin Ichim, Anthony Booker

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