St John's wort modulation and developmental expression of multidrug transporters in the rat

Phytotherapy Research : PTR
Chiara GarrovoGiuliana Decorti

Abstract

Extracts of St John's wort (SJW) (Hypericum perforatum) are a potent inducer of enzymes of the cytochrome P450 system and of the transport protein P-glycoprotein, and interactions with a range of commonly prescribed medications have been described. In addition, recent experimental data suggest that, this otherwise safe treatment, could have some side effects when consumed during pregnancy and lactation. The aim of this study was to investigate, in Wistar rats, the effect of a treatment with high doses of SJW extract (100 and 1000 mg/kg/day) administered prenatally and during breastfeeding, on the level of transcripts of mdr1a, mdr1b, mrp1, mrp2 and cyp3A2 genes. All transcripts were detected in the liver, and their level of expression increased from fetuses to adults. SJW administration, at both dosages, caused a significant decrease of the levels of mdr1a, mdr1b, mrp1 and mrp2 in the livers of fetuses, and an increase in the levels of mdr1a, mdr1b, mrp2 and cyp3A2 in the mothers. In the other organs examined, a physiological regulation during ontogenesis was also evident, but SJW administration did not modify the expression level of the considered transcripts. These data suggest that the administration of the extract together ...Continue Reading

References

Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·G ConseilA Di Pietro
Dec 22, 1998·European Journal of Clinical Pharmacology·E ErnstC Stevinson
May 20, 1999·The Annals of Pharmacotherapy·A NebelD J Kroll
Jan 7, 2000·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·C Stevinson, E Ernst
Feb 16, 2000·Lancet·A Fugh-Berman
Feb 22, 2000·Lancet·S C PiscitelliJ Falloon
May 29, 2000·Clinical Pharmacology and Therapeutics·C A RobyA H Burstein
Jun 15, 2000·Proceedings of the National Academy of Sciences of the United States of America·L B MooreS A Kliewer
Nov 10, 2000·International Journal of Clinical Pharmacology and Therapeutics·I MaiI Roots
Nov 21, 2000·American Journal of Obstetrics and Gynecology·W F RayburnC L Gonzalez
Feb 15, 2001·American Journal of Obstetrics and Gynecology·W F RayburnJ D Stewart
Feb 17, 2001·Clinical Pharmacology and Therapeutics·D DürrK Fattinger
Apr 20, 2001·Mechanisms of Ageing and Development·M SchiengoldN B Nardi
May 16, 2001·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·B MahmoodJ F Watchko
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A D MottinoM Vore
Dec 12, 2001·British Journal of Pharmacology·M D PerloffD J Greenblatt
Jan 17, 2002·Neurotoxicology and Teratology·W F RayburnT C Kupiec
Jan 24, 2002·Journal of Bioenergetics and Biomembranes·M M Gottesman, S V Ambudkar
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vadim S ZinchukHarumichi Seguchi
Feb 19, 2002·British Journal of Clinical Pharmacology·Martina HennessyJ Feely
May 15, 2002·Life Sciences·Anna Rita BiliaFranco F Vincieri
Jun 28, 2002·Clinical Pharmacology and Therapeutics·Zaiqi WangStephen D Hall
Aug 22, 2002·Journal of the National Cancer Institute·Ron H J MathijssenAlex Sparreboom
Dec 18, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Elaine M LeslieSusan P C Cole
Jan 16, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tyra M Leazer, Curtis D Klaassen
Jan 25, 2003·Clinical Pharmacology and Therapeutics·George K DresserRichard B Kim
Sep 3, 2003·Development, Growth & Differentiation·Anna RosatiFiora Bartoli
Apr 28, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y ShibayamaK Yamada
Sep 8, 2004·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Marcus Mannel
Oct 27, 2004·Toxicology and Applied Pharmacology·Barbara GregorettiGiuliana Decorti
Jan 1, 1999·Methods in Molecular Medicine·S E BatesE Gamelin

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Citations

Jan 28, 2010·Pharmacological Reviews·Curtis D Klaassen, Lauren M Aleksunes
Jan 20, 2012·Clinical Pharmacokinetics·Shaojun Shi, Ulrich Klotz
Aug 27, 2010·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenElina Sieppi
Mar 18, 2010·Drug Metabolism Reviews·Xinsheng Gu, Jose E Manautou
Oct 10, 2009·Integrative Cancer Therapies·Stacy S ShordAlvina Lukose

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