Stability and aerosolization of pressurized metered dose inhalers containing thymopentin nanoparticles produced using a bottom-up process

International Journal of Pharmaceutics
Yinhe TanChuanbin Wu

Abstract

The objective of this study was to investigate the stability and aerosolization of pressurized metered dose inhalers (pMDIs) containing thymopentin nanoparticles. Thymopentin nanoparticles, fabricated by a bottom-up process, were suspended in hydrofluoroalkane (HFA) 134a together with cineole and/or n-heptane to produce pMDI formulations. The stability study of the pMDIs obtained was carried out at ambient temperature for 6 months. The amount of thymopentin and the aerosolization properties of pMDIs were determined using high-performance liquid chromatography (HPLC) and a twin-stage impinger (TSI), respectively. Based on the results, thymopentin nanoparticles were readily suspended in HFA 134a with the aid of cineole and/or n-heptane to form physically stable pMDI formulations, and more than 98% of the labeled amount of thymopentin and over 50% of the fine particle fraction (FPF) of the pMDIs were achieved. During storage, it was found that for all pMDIs more than 97% of the labeled amount of thymopentin and FPF greater than 47% were achieved. Moreover, the size of thymopentin nanoparticles in propellant containing cineole and n-heptane showed little change. It is, therefore, concluded that the pMDIs comprising thymopentin nano...Continue Reading

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Jul 24, 2013·International Journal of Pharmaceutics·Somchai SawatdeeTeerapol Srichana
Jan 24, 2014·AAPS PharmSciTech·Paul B MyrdalStephen W Stein
Feb 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xi HuShiqi Peng
Oct 30, 2020·Pharmaceutics·Wanling LiangJenny K W Lam

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