Stability and bioavailability of vitamin D nanoencapsulated in casein micelles

Food & Function
Michal HahamYoav D Livney

Abstract

We have previously introduced the potential of casein micelles (CM) as natural nanovehicles for hydrophobic nutraceuticals, e.g. vitamin D (VD) (E. Semo, E. Kesselman, D. Danino and Y. D. Livney, Food Hydrocolloids, 2007, 21, 936-942). The aims of the current study were to improve performance by adding an ultra-high-pressure homogenization step, and to evaluate the protection conferred by re-assembled CM (rCM) against VD thermal and oxidative degradation, and the bioavailability of VD(3) in rCM, by a clinical trial. Dynamic-light-scattering showed that VD(3)-rCM had a diameter of 91 ± 8 nm (average ± standard error). When VD(3) was encapsulated in rCM and subjected to thermal treatment (80 °C, 1 min), no significant loss was observed (P > 0.05), compared to 13 and 14% loss of VD(3) emulsified with Tween-80 (a synthetic emulsifier typically used for VD solubilization) and of unencapsulated VD(3) respectively (P < 0.05). VD(3) in rCM was also more stable during 28 d cold storage (∼40% loss) compared to Tween-80 emulsified (∼50% loss) or to un-encapsulated (∼70% loss) VD(3). Ultra-high-pressure homogenization of VD(3)-rCM (∼155 MPa) significantly enhanced vitamin stability, resulting in only ∼10% loss after 28 d of storage. Bioava...Continue Reading

References

Apr 1, 1979·The Journal of Dairy Research·A M KnoopA Wiechen
Apr 30, 1992·The New England Journal of Medicine·C H JacobusE W Seely
Feb 1, 1982·Journal of Pharmaceutical Sciences·K T Koshy
Jun 7, 2003·The American Journal of Clinical Nutrition·Vin TangprichaMichael F Holick
Feb 27, 2004·The American Journal of Clinical Nutrition·Michael F Holick
Mar 15, 2006·Mayo Clinic Proceedings·Michael F Holick
Jul 20, 2007·The New England Journal of Medicine·Michael F Holick
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Reinhold Vieth
Mar 11, 2008·The American Journal of Clinical Nutrition·Marium IlahiRobert P Heaney
Jun 24, 2008·The Journal of Nutrition·Dennis WagnerReinhold Vieth
Jul 21, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Alina ShapiraYoav D Livney
Oct 20, 2010·European Journal of Clinical Investigation·Arie SteinvilOri Rogowski
Dec 2, 2010·The Journal of Clinical Endocrinology and Metabolism·A Catharine RossSue A Shapses
Jun 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Michael F HolickUNKNOWN Endocrine Society

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Citations

Dec 3, 2013·Pharmaceutical Development and Technology·Umile Gianfranco SpizzirriFrancesca Iemma
Dec 3, 2014·Food Chemistry·Fatoumata DiarrassoubaMuriel Subirade
May 26, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A BoulierA Blais
Jul 9, 2016·International Journal of Food Sciences and Nutrition·Roberta TolveZhibing Zhang
Aug 1, 2016·Journal of Dairy Science·Jannik Nedergaard PedersenDaniel E Otzen
Aug 15, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Naaman F Nogueira SilvaFrédéric Gaucheron
Jun 14, 2017·Critical Reviews in Food Science and Nutrition·Nauman KhalidMitsutoshi Nakajima
Feb 27, 2018·Chemical Society Reviews·Christopher D SpicerMolly M Stevens
Jan 15, 2018·Journal of Dairy Science·Jannik Nedergaard PedersenDaniel E Otzen
Apr 25, 2019·Critical Reviews in Food Science and Nutrition·Angélica M Serpa GuerraRobin Zuluaga Gallego
Mar 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javiera Mujica-ÁlvarezSilvia Matiacevich
Jan 7, 2020·Annual Review of Food Science and Technology·David Julian McClements
Jun 6, 2020·Food & Function·Ida Emilie I LindahlHanne Christine Bertram
Jul 17, 2013·Advances in Nutrition·Alexandra Schmid, Barbara Walther
Jan 1, 2013·Faraday Discussions·Anne KesslerJochen Weiss
Mar 21, 2017·Journal of Animal Science and Biotechnology·Emily K Hill, Julang Li
Jul 18, 2017·Topics in Current Chemistry·Tomasz Konrad Głąb, Janusz Boratyński
Jul 22, 2019·Pharmaceutics·Eliza GlowkaJanina Lulek
Mar 9, 2019·Food Science & Nutrition·Parisa MalekhosseiniSeyed Mohammad Hashem Hosseini
Dec 17, 2017·Drug Delivery and Translational Research·Hye-Gyeong KimYeu-Chun Kim
Nov 15, 2019·Science Translational Medicine·Aaron C AnselmoAna Jaklenec
Dec 19, 2020·Journal of Pharmaceutical Sciences·K C BarickP A Hassan
Apr 10, 2021·Journal of Agricultural and Food Chemistry·Ever Hernández-OlivasAna Heredia
May 3, 2021·Advances in Colloid and Interface Science·Chuan-He Tang
Apr 28, 2019·International Journal of Biological Macromolecules·Eliara Acipreste HudsonLuis Henrique Mendes da Silva

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