Stability and compatibility of tegaserod from crushed tablets mixed in beverages and foods

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Marie-Noëlle CarrierChristian Vitzling

Abstract

The stability and compatibility of tegaserod from crushed tablets in selected beverages and foods were studied. Suspensions of tegaserod maleate tablets containing 6 mg of the drug base were prepared by crushing the tablets and mixing the powder with tap water, apple juice, orange juice, milk, applesauce, yogurt, and chocolate-hazelnut spread. Drug stability, drug comparability, suspension homogeneity, and completeness of a dose were measured by high-performance liquid chromatography at intervals up to three days at 20-25 degrees C and 5 degrees C. In vitro dissolution profiles were determined for crushed tegaserod tablets in water, apple juice, orange juice, and applesauce. Tegaserod from crushed tablets was stable in and compatible with water, apple juice, orange juice, and applesauce, and the suspensions were homogeneous. The complete dose was delivered with these media. The dissolution profiles of crushed tegaserod tablets in water and in apple juice were comparable to those of intact tablets; the dissolution profiles in orange juice and applesauce were not comparable with those of intact tablets. The results with milk, yogurt, and chocolate-hazelnut spread as vehicles were inconclusive. The suspension in milk was not homog...Continue Reading

Citations

May 5, 2012·The International Journal of Pharmacy Practice·Gazala Akram, Alexander B Mullen
Nov 18, 2015·European Journal of Clinical Pharmacology·Aoife Mc GillicuddyLaura J Sahm
Mar 20, 2015·Fundamental & Clinical Pharmacology·Gwladys BourdenetJean Doucet
Dec 29, 2007·Journal of Pediatric Gastroenterology and Nutrition·Olivia LiemCarlo Di Lorenzo
Jul 18, 2021·Clinical Pharmacology in Drug Development·Alex YuAnasuya Hazra

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