Stability and degradation kinetics of meropenem in powder for injection and reconstituted sample

Journal of Pharmaceutical and Biomedical Analysis
Andreas MendezE E S Schapoval

Abstract

The stability of broad-spectrum antibiotic meropenem was studied in order to investigate the kinetics of degradation of this drug in powder for injection and reconstituted sample. Carbapenem was submitted to conditions of accelerated thermal decomposition. Degradation of meropenem was adequately modeled by specific equations for order rate kinetics. The analyses of the degraded samples were performed by high-performance liquid chromatographic (HPLC) method and microbiological assay. At higher temperatures, the decomposition reactions of meropenem in powder for injection could be described by first-order kinetics. The higher rate of degradation was observed in meropenem reconstituted in 0.9% sodium chloride, and the thermal decomposition obeyed also first-order kinetics. The results obtained confirm the reliability of chromatographic method for determining the kinetics run of meropenem in the presence of its degradation products. The present study reveals the thermal lability of the drug, especially as reconstituted sample. Thus, appropriate thermal protection is recommended during the storage and handling.

References

Mar 1, 1997·International Journal of Antimicrobial Agents·J L Blumer

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Citations

Mar 28, 2012·Antimicrobial Agents and Chemotherapy·Kathleen EnglandClifton E Barry
Jun 17, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Joseph WongG Joseph Ray
Feb 13, 2015·Drug Development and Industrial Pharmacy·Rohit JainIan G Tucker
Nov 26, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Magdalena PaczkowskaJudyta Cielecka-Piontek
Jun 3, 2015·Systematic and Applied Microbiology·Windy D TannerRobyn M Atkinson
Oct 9, 2015·Hospital Pharmacy·Cristina TomaselloAntonio D'Avolio
Jan 31, 2017·Biomedical Chromatography : BMC·Fábio de Souza BarbosaAndreas Sebastian Loureiro Mendez
Jul 31, 2014·The Journal of Antibiotics·Judyta Cielecka-PiontekPiotr Garbacki
Jul 27, 2018·Biomedical Chromatography : BMC·José Pedro Etchepare CassolAndreas S L Mendez
Oct 10, 2018·Scientific Reports·Belén OlivaresPaola R Campodonico
Feb 5, 2021·International Journal of Pharmaceutics·Aun RazaJames R Falconer
Nov 5, 2021·Orthopaedic Surgery·Li-Hong WangGuo-Hong Xu

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