PMID: 2494369Jan 1, 1989Paper

Stability and delivery of vancomycin hydrochloride when admixed in a total parenteral nutrition solution

JPEN. Journal of Parenteral and Enteral Nutrition
C G SchillingD L Uden

Abstract

Vancomycin hydrochloride, 400 mg/liter was mixed in six standard pediatric parenteral nutrition solutions with and without heparin added. The solutions were stored over a period of 8 days (192 hr) under refrigeration and at room temperature. Aliquots from all six solutions were assayed in duplicate for vancomycin at time 0, 24, 96, and 192 hr. All samples were run through an Ivex 0.22-micron filter, observed for physical incompatibilities, and frozen at -70 degrees C until assay. Our results indicate that vancomycin was stable and was delivered with loss in concentration of less than 5% with and without storage under refrigeration. This study suggests an alternative method for delivering vancomycin when treating a catheter-related infection. If vancomycin is delivered in this fashion, less manipulations of the line would be required. In addition, there may be a theoretical advantage of constantly bathing the catheter with vancomycin when the catheter is suspected of harboring the infecting organism.

References

Mar 1, 1985·JPEN. Journal of Parenteral and Enteral Nutrition·D Watson
Dec 1, 1985·Journal of Pediatric Surgery·D R KingR P Harmel

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Citations

Aug 1, 1994·The Journal of Pediatrics·M A KacicaR A Venezia
Sep 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·A M MartinsK McErlane
Jan 1, 2014·The Pediatric Infectious Disease Journal·Amanda GweeNigel Curtis
Nov 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·G HardyB McElroy
Sep 2, 1998·British Journal of Clinical Pharmacology·F PawlotskyJ C Roze

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