Stability and functional correlates of memory-based classification in older schizophrenia patients

The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry
Christopher R BowiePhilip D Harvey

Abstract

There is an increasing interest in the usefulness of neurocognitive subtyping of schizophrenia. The classification of schizophrenia patients with cortical versus subcortical impairments has recently been validated with both neuropsychological and neurobiological measures. The authors examined the stability and correlations of these classifications with longitudinal assessments in older, chronically ill schizophrenia patients. Older, chronically ill patients (N=589) were classified on the basis of their baseline profile, and a subset (N=243) was followed for periods up to 8 years, with data analyses conducted to evaluate the stability of these profiles, to determine whether classification into cortical or subcortical impairment at baseline predicts changes in self-care and social functioning at endpoint, up to 8 years later. Cortical profiles were most common and most stable over time, with the majority of patients with a subcortical profile at baseline found to have a cortical profile at follow-up. Those patients whose subcortical impairment profile was stable over time had less severe cognitive and functional impairments at baseline than those whose profile was found to be cortical at follow-up. Cortical profiles of memory imp...Continue Reading

Citations

Dec 1, 2006·Neuropsychiatric Disease and Treatment·Christopher R Bowie, Philip D Harvey
Aug 25, 2007·Annual Review of Clinical Psychology·Philip D HarveyChristopher R Bowie

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