PMID: 8581460Nov 1, 1995Paper

Stability and stabilization of insulinotropin in a dextran formulation

PDA Journal of Pharmaceutical Science and Technology
H Qi, D L Heller

Abstract

The stability of insulinotropin in a formulation containing 23% dextran-75 is studied. The effects of temperature, excipients, dextran concentration, and drug concentration on the stability of insulinotropin are examined. The tryptophan residue is identified as the primary degradation site in the insulinotropin molecule by LC-MS. Different antioxidants are used to stabilize the peptide. The combination of cysteine and EDTA is found to be most effective in stabilizing insulinotropin in the dextran formulation.

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