Stability and treatment outcome of distinct classes of mania

European Psychiatry : the Journal of the Association of European Psychiatrists
Inge van RossumEMBLEM Advisory Board

Abstract

Psychopathological heterogeneity in manic syndromes may in part reflect underlying latent classes with characteristic outcome patterns. Differential treatment course and outcome after 12 weeks of treatment were examined for three distinct classes of patients with acute mania in bipolar disorder. Three thousand four hundred and twenty-five patients with acute mania were divided into three distinct mania classes: 'Typical', 'Psychotic' and 'Dual' (i.e. comorbid substance use) mania. Persistence of class differences and social outcomes were examined, using multilevel regression analyses and odds ratios. The three classes showed substantial stability post-baseline in the pattern of associations with class-characteristic variables. Psychotic and Dual mania predicted poorer outcome in terms of psychosis comorbidity and overall bipolar and mania severity, while Dual mania additionally predicted poorer outcome of alcohol and substance abuse. Worse social outcomes were observed for both Dual and Psychotic mania. The identified distinct classes are stable and associated with differential treatment outcome. Overall, Dual and Psychotic mania show less favourable outcomes compared to Typical mania. These findings additionally give rise to c...Continue Reading

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Citations

Nov 17, 2009·Current Psychiatry Reports·Alan C Swann
Nov 6, 2010·CNS Neuroscience & Therapeutics·Katherine Kovalski Busby, Martha Sajatovic
May 20, 2015·Journal of Affective Disorders·C Mar BonnínEduard Vieta
May 6, 2015·Journal of Psychiatric Research·Tomihisa NiitsuAlessandro Serretti
Jan 20, 2019·The Australian and New Zealand Journal of Psychiatry·Alfredo Carlo AltamuraUNKNOWN ISBD Italian Chapter Epidemiological Group
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Apr 1, 2013·Journal of Substance Use·Beau AbarEdwin D Boudreaux

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