Stability improvement and characterization of bioprinted pectin-based scaffold

Journal of Applied Biomaterials & Functional Materials
Samuel StealeyWujie Zhang

Abstract

Bioprinting is an alternative method for constructing tissues/organs for transplantation. This study investigated the cross-linker influence and post-printing modification using oligochitosan and chitosan for stability improvement. Oligochitosan was tested as a novel cross-linker to replace Ca2+ for pectin-based bio-ink. Oligochitosan (2 kD) and different molecular weight of chitosan were used to modify the bioprinted scaffold. Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) were used to characterize the scaffolds. Oligochitosan failed to serve as a viable cross-linker. Successful post-printing modification was confirmed by FTIR and SEM analyses. Regarding post-modification, chitosan-treated scaffolds showed enhanced stability compared to untreated scaffolds. In particular, scaffolds modified with 150 kD chitosan exhibited the highest stability.

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Citations

Jul 2, 2020·International Journal of Molecular Sciences·Tabata SatoAlexandre Borges
Apr 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Shuxian HuPaul de Vos
Dec 21, 2021·Frontiers in Bioengineering and Biotechnology·Matteo PittonNicola Contessi Negrini

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Methods Mentioned

BETA
bioprinter
bioprinting
scanning electron microscopy

Software Mentioned

Code
Slicr
Repetier
BioBot
Host

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