Stability of 11C-labeled PET radiopharmaceuticals

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
Toshimitsu FukumuraKazutoshi Suzuki

Abstract

The stability of widely used 11C-radiopharmaceuticals was investigated. The purity of many 11C-radiopharmaceuticals was found to be low even at the end of synthesis and to lower with time by radiolysis. Examinations of the effects of radical scavengers showed that the radiopharmaceuticals were classified into four groups: Group 1 showing excellent stability; Group 2 showing suppressed radiolysis in the presence of a selective scavenger of hydroxyl radicals; Group 3 showing suppression in the presence of a selective scavenger of hydrated electrons; Group 4 showing suppression in the presence of both scavengers. Using appropriate additives according to these classes, 11C-radiopharmaceuticals were prepared with excellent radiochemical purity even with high levels of radioactivity and specific activity.

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Citations

Jan 27, 2011·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·David ThononAndré Luxen
May 22, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Maki OkadaOsamu Inoue
Dec 25, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Erik de BloisWouter A P Breeman
Jun 27, 2014·Pharmaceuticals·Markus Mitterhauser, Wolfgang Wadsak
Dec 17, 2011·Nuclear Medicine and Biology·Filippo LodiStefano Boschi
Oct 12, 2010·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Kotaro NagatsuKazutoshi Suzuki
Feb 24, 2009·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Mark S JacobsonDouglas W Mahoney
Oct 28, 2008·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Peter J H ScottMichael R Kilbourn
Jul 29, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Lisa BacherCarmen Wängler
Mar 19, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Xia ShaoPeter J H Scott
Jan 1, 2017·EJNMMI Radiopharmacy and Chemistry·Michael WoodsKuo-Shyan Lin

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