PMID: 9188573Jul 1, 1997Paper

Stability of AML1 (core) site enhancer mutations in T lymphomas induced by attenuated SL3-3 murine leukemia virus mutants

Journal of Virology
H W AmtoftF S Pedersen

Abstract

Murine retrovirus SL3-3 is highly T lymphomagenic. Its pathogenic properties are determined by the transcriptional enhancer of the U3 repeat region which shows preferential activity in T cells. Within the U3 repeats, the major determinant of T-cell specificity has been mapped to binding sites for the AML1 transcription factor family (also known as the core binding factor [CBF], polyomavirus enhancer binding protein 2 [PEBP2], and SL3-3 enhancer factor 1 [SEF-1]). SL3-3 viruses with AML1 site mutations have lost a major determinant of T-cell-specific enhancer function but have been found to retain a lymphomagenic potential, although disease induction is slower than for the SL3-3 wild type. To compare the specificities and mechanisms of disease induction of wild-type and mutant viruses, we have examined lymphomas induced by mutant viruses harboring transversions of three consecutive base pairs critical to AML1 site function (B. Hallberg, J. Schmidt, A. Luz, F. S. Pedersen, and T. Grundström. J. Virol. 65:4177-4181, 1991). Our results show that the mutated AML1 sites are genetically stable during lymphomagenesis and that ecotropic provirus numbers in DNA of tumors induced by wild-type and mutant viruses fall within the same range....Continue Reading

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H M ProsserM J Owen
Jul 11, 1988·Nucleic Acids Research·B Hallberg, T Grundström
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D Steffen
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·E OgawaY Ito

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Citations

Jan 19, 2007·Journal of Virology·Jennifer A MertzJaquelin P Dudley
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ke-Zheng DaiAnne Spurkland

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