Stability of an extemporaneously compounded minoxidil oral suspension

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Yunmei SongSanjay Garg

Abstract

Results of a study to determine the stability of an extemporaneously compounded minoxidil oral suspension under various temperature and stress conditions are reported. Commercially available minoxidil tablets (10 mg) were crushed to a fine powder, and predetermined amounts of 2 suspending vehicles were added to produce a 1-mg/mL suspension, which was stored in glass bottles at room temperature (25 ± 2 °C) or in a refrigerator (4 ± 2 °C). To simulate daily patient use, 5 days weekly 1 bottle of the suspension was removed from refrigerated storage and shaken and 0.5 mL of the contents discarded. At each specified time point, samples were analyzed in duplicate (n = 6 for each test condition) using a validated high-performance liquid chromatography method. Samples were visually observed and their pH measured at each time point. Microbiological studies were performed on day 0 and at week 24. The mean percentage of initial minoxidil concentration remaining in all refrigerated samples exceeded 90% throughout the 24-week study, with no change in appearance, pH, microbial activity, odor, or redispersibility. During storage at room temperature, the suspension exhibited a color change at week 4, with slight sedimentation after 6 weeks, al...Continue Reading

References

Jan 1, 1980·Journal of Cardiovascular Pharmacology·A R SinaikoB L Mirkin
Aug 14, 2003·The American Journal of Cardiology·On Topaz
Aug 12, 2008·Current Drug Safety·Therése Eileen KairuzSanjay Garg
Feb 24, 2012·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Hinemoa Elder

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