Stability of antibody-conjugated gold nanoparticles in the endolysosomal nanoenvironment: implications for noninvasive radiofrequency-based cancer therapy.

Nanomedicine : Nanotechnology, Biology, and Medicine
Mustafa RaoofSteven A Curley

Abstract

The use of noninvasive radiofrequency (RF) electric fields as an energy source for thermal activation of nanoparticles within cancer cells could be a valuable addition to the emerging field of nano-mediated cancer therapies. Based on investigations of cell death through hyperthermia, and offering the ability for total-body penetration by RF fields, this technique is thought to complement and possibly outperform existing nano-heat treatments that utilize alternative heat production via optical or magnetic stimuli. However, it remains a challenge to understand fully the complex RF-nanoparticle-intracellular interactions before full system optimization can be engineered. Herein we have shown that liver cancer cells can selectively internalize antibody-conjugated gold nanoparticles (AuNPs) through receptor-mediated endocytosis, with the nanoparticles predominantly accumulating and aggregating within cytoplasmic endolysosomes. After exposure to an external RF field, nonaggregated AuNPs absorbed and dissipated energy as heat, causing thermal damage to the targeted cancer cells. We also observed that RF absorption and heat dissipation is dependent on solubility of AuNPs in the colloid, which is pH dependent. Furthermore, by modulating...Continue Reading

References

Jan 1, 1993·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A JordanR Felix
Jan 12, 2001·Journal of Photochemistry and Photobiology. B, Biology·S StolikL Anasagasti
May 15, 2003·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·James R Lepock
Mar 18, 2004·Bioconjugate Chemistry·Moritz F KircherLee Josephson
Jul 16, 2004·Journal of Endourology·Manfred JohannsenStefan Loening
May 19, 2005·Bioconjugate Chemistry·Pei-Hui YangQing-Yu He
Sep 23, 2006·Nature Reviews. Cancer·Mona Mostafa Mohamed, Bonnie F Sloane
Oct 4, 2007·Nature Reviews. Molecular Cell Biology·Michael Forgac
Apr 16, 2009·Nano Letters·Rachela PopovtzerRaoul Kopelman
Sep 5, 2009·ACS Nano·Violaine SéeRaphaël Lévy
Oct 24, 2009·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A JordanR Felix
Nov 11, 2009·Chemistry : a European Journal·In-Cheol SunCheol-Hee Ahn
Nov 17, 2009·Advanced Drug Delivery Reviews·Paul CherukuriSteven A Curley
Dec 17, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dakrong PissuwanMichael B Cortie
Jun 19, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Ariel R GuerreroMarcelo J Kogan
Dec 9, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Evan S GlazerSteven A Curley
Mar 16, 2011·IEEE Transactions on Bio-medical Engineering·Dustin E KruseKatherine W Ferrara
Mar 25, 2011·Journal of Colloid and Interface Science·Dongxiao LiDavid A Geller

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Citations

Nov 28, 2013·Chemical Reviews·Lev A Dykman, Nikolai G Khlebtsov
Jan 1, 2014·International Journal of Nanomedicine·Katarzyna PalaJacek Otlewski
Mar 10, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·N Sanoj RejinoldYeu-Chun Kim
Dec 20, 2012·Nanomedicine·Alyssa M Master, Anirban Sen Gupta
Apr 29, 2014·Bulletin of Experimental Biology and Medicine·G V RevaV V Chaika
Apr 30, 2013·Pharmaceutical Research·Qiaoya LinGang Zheng
May 27, 2014·Biotechnology Advances·João Pinto da CostaRui Vitorino
Jun 5, 2012·ACS Nano·Stefaan J SoenenKevin Braeckmans
Jun 25, 2013·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Stuart J CorrSteven A Curley
Jul 23, 2013·Nanomedicine : Nanotechnology, Biology, and Medicine·Samina NazirAlexander John MacRobert
Sep 27, 2013·Materials Science & Engineering. R, Reports : a Review Journal·Hongmin ChenJin Xie
Sep 17, 2015·Journal of Experimental & Clinical Cancer Research : CR·Li FanBoquan Jin
Jan 29, 2013·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Boi Hoa SanKyeong Kyu Kim
Feb 24, 2015·International Journal of Pharmaceutics·Omkara Swami MuddinetiSwati Biswas
Dec 3, 2014·Nanomedicine : Nanotechnology, Biology, and Medicine·Renat R LetfullinThomas F George
Jan 24, 2015·Journal of Biotechnology·Mohan C M ArachchigeOleg A Andreev
Dec 21, 2014·International Journal of Biological Macromolecules·N Sanoj RejinoldR Jayakumar
Jun 1, 2016·Colloids and Surfaces. B, Biointerfaces·Yasmine AbbasSanjay Mathur
Jun 7, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jaber BeikS Kamran Kamrava
Oct 19, 2016·Chemical Communications : Chem Comm·Nadia C LaraStuart J Corr
Mar 2, 2018·Lasers in Medical Science·Hasan NorouziFatemeh Akbarzadeh
Aug 3, 2016·Nanomedicine·Dimitrios KarponisAlexander Seifalian
Feb 19, 2019·Small·Huijing Xiang, Yu Chen
May 30, 2019·Biomolecules·Benjamin D WhiteHelen E Townley
Jan 22, 2014·Nanoscale·Joseph A Webb, Rizia Bardhan
Apr 3, 2020·Electromagnetic Biology and Medicine·Sundeep Singh, Roderick Melnik
Oct 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rumi KhandeliaArun Chattopadhyay
Aug 14, 2018·ChemMedChem·Caterina CamodecaArmando Rossello
Sep 1, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Majid SharifiMojtaba Falahati
Apr 1, 2021·Journal of Biomedical Nanotechnology·Bin ZhangHuashi Guan
May 9, 2016·ACS Biomaterials Science & Engineering·Vijay Harish SomasundaramManzoor Koyakutty
Jul 20, 2018·ACS Omega·Kaushik BeraNakul C Maiti
Aug 10, 2017·ACS Applied Materials & Interfaces·Sajid FazalDeepthy Menon

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