Sep 1, 1983

Stability of aspirin in different media

Journal of Pharmaceutical Sciences
S K Bakar, S Niazi

Abstract

Aspirin rapidly hydrolyzes in various aqueous, organic, and biological media. The purpose of this investigation was to study the decomposition of aspirin in the media that comes in contact with it during analysis in biological fluids for pharmacokinetic studies. These media included water, water-polyethylene glycol 400, water-methanol-acetic acid, phosphate buffer, freshly drawn blood and plasma from control rats and rats deprived of water for 36 hr, and blood precipitated with acetonitrile. Studies were also conducted to determine the decomposition as a function of temperature and pH. Of the various solvent systems studied, aspirin was found most stable in water-polyethylene glycol (4:1, v/v),which provides an excellent medium for preparation of intravenous dosage forms. Phosphate buffer showed significant catalysis of aspirin hydrolysis. A more than fivefold increase in the hydrolysis of aspirin was noted when the temperature was raised to 37 degrees from 22.5 degrees. The hydrolysis of aspirin in rat blood was 13 times faster than that in plasma, with an average half-life in blood of approximately 13 min. This creates significant problems in aspirin disposition kinetic studies. Mixing the blood sample immediately after colle...Continue Reading

  • References
  • Citations10

References

  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Pathologic Cytolysis
Phosphate buffers
Zorprin
Body Fluids
Polyethylene Glycols
Solvents
In Blood
Drug Stability
Body Fluids and Substances
Blood Cells

About this Paper

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.

Related Papers

Current Drug Delivery
Erik JämstorpMaria Strømme
Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Michal KralPetr Kanovsky
© 2020 Meta ULC. All rights reserved