Stability of bovine spongiform encephalopathy prions: absence of prion protein degradation by bovine gut microbiota

Zoonoses and Public Health
C BöhnleinManfred Gareis

Abstract

Bovine spongiform encephalopathy (BSE) is transmitted by the oral route. However, the impacts of anaerobic fermentation processes in cattle on the stability of BSE-associated prion protein (PrP(Sc)) are still unresolved. In this study, experiments were designed to assess the ability of complex ruminal and colonic contents of bovines to degrade BSE-derived PrP(Sc). No significant decrease in PrP(Sc) levels in BSE brain homogenates was detected by Western blotting after up to 66 h of co-incubation with intestinal fluids. These results indicate that BSE-associated PrP(Sc) survive gastrointestinal digestion processes in cattle and might be excreted via faeces.

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Citations

May 20, 2016·The Journal of General Virology·David S Donaldson, Neil A Mabbott
Oct 17, 2013·Transboundary and Emerging Diseases·D González-BarrioF Ruiz-Fons
Aug 8, 2019·Scientific Reports·Alba Marín-MorenoJuan María Torres
Jan 31, 2020·Food Safety·Susumu KumagaiTakashi Onodera

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