Stability of carotid artery under steady-state and pulsatile blood flow: a fluid-structure interaction study

Journal of Biomechanical Engineering
Seyed Saeid Khalafvand, Hai-Chao Han

Abstract

It has been shown that arteries may buckle into tortuous shapes under lumen pressure, which in turn could alter blood flow. However, the mechanisms of artery instability under pulsatile flow have not been fully understood. The objective of this study was to simulate the buckling and post-buckling behaviors of the carotid artery under pulsatile flow using a fully coupled fluid-structure interaction (FSI) method. The artery wall was modeled as a nonlinear material with a two-fiber strain-energy function. FSI simulations were performed under steady-state flow and pulsatile flow conditions with a prescribed flow velocity profile at the inlet and different pressures at the outlet to determine the critical buckling pressure. Simulations were performed for normal (160 ml/min) and high (350 ml/min) flow rates and normal (1.5) and reduced (1.3) axial stretch ratios to determine the effects of flow rate and axial tension on stability. The results showed that an artery buckled when the lumen pressure exceeded a critical value. The critical mean buckling pressure at pulsatile flow was 17-23% smaller than at steady-state flow. For both steady-state and pulsatile flow, the high flow rate had very little effect (<5%) on the critical buckli...Continue Reading

References

Jan 1, 1988·Journal of Biomechanics·H Demiray
May 2, 2003·Annals of Biomedical Engineering·Hai-Chao HanRaymond P Vito
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Mar 31, 2005·Journal of Biomechanical Engineering·Wei ZhangGhassan S Kassab
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Nov 4, 2006·Medical Engineering & Physics·Biyue Liu
Aug 11, 2007·Journal of Biomechanics·Hai-Chao Han
Sep 11, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Yunlong HuoGhassan S Kassab
May 20, 2008·Journal of Biomechanics·Samuel A KockW Yong Kim
Jul 26, 2008·Journal of Biomechanics·Hai-Chao Han
Apr 25, 2009·Journal of Biomechanical Engineering·Alexander Rachev
Sep 18, 2009·Journal of Biomechanics·Hai-Chao Han
Oct 17, 2009·Journal of Biomechanical Engineering·Qingping YaoHai-Chao Han
Jun 9, 2010·Journal of Biomechanical Engineering·Hai-Chao Han
Dec 14, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Avione Y LeeHai-Chao Han
Dec 31, 2011·Journal of Biomechanical Engineering·Jennifer K W Chesnutt, Hai-Chao Han
Oct 5, 2010·International Journal of Applied Mechanics·Parag DatirHai-Chao Han
Feb 24, 2012·Journal of Biomechanics·Qin Liu, Hai-Chao Han
Mar 22, 2012·Journal of Vascular Research·Hai-Chao Han
Nov 30, 2012·Annals of Biomedical Engineering·Hai-Chao HanQi Wen
Jun 16, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Yangming XiaoHai-Chao Han
Jun 29, 2014·Journal of Biomechanics·Qin LiuHai-Chao Han

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Citations

Feb 16, 2018·Computer Methods in Biomechanics and Biomedical Engineering·Mohammadali SharzeheeHai-Chao Han
Nov 16, 2017·Scientific Reports·Selda GoktasKerem Pekkan
Feb 26, 2016·Annals of Biomedical Engineering·Yangming XiaoHai-Chao Han
Nov 5, 2019·International Journal for Numerical Methods in Biomedical Engineering·Mohammadali SharzeheeHai-Chao Han

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