Stability of curcumin in oil-in-water emulsions: Impact of emulsifier type and concentration on chemical degradation

Food Research International
Mahesh KharatDavid Julian McClements

Abstract

Oral ingestion of curcumin is claimed to be effective against several diseases, including inflammation and cancer. However, its utilization in food, supplement, and pharmaceutical products is often challenging due to its poor water solubility, high chemical instability, and limited oral bioavailability. Emulsion-based delivery systems can be designed to overcome these challenges, but their composition and structure must be optimized to ensure they function appropriately. This study examined the impact of emulsifier type on the formation and stability of curcumin-loaded oil-in-water emulsions: sodium caseinate; Tween 80; quillaja saponin; gum arabic. The effectiveness of these food-grade emulsifiers at forming emulsions by microfluidization was characterized in terms of their surface load, i.e., the mass of emulsifier per unit surface area. The surface loads decreased in the following order: gum arabic (55.3 mg/m2) > > saponins (2.0 mg/m2) > Tween 80 (1.6 mg/m2) > caseinate (1.5 mg/m2), which indicated that much more gum arabic was required to form emulsions than the other emulsifiers. Curcumin-loaded emulsions were then prepared under conditions where there was just enough emulsifier to cover the droplet surfaces ("critical"), ...Continue Reading

References

Jun 1, 1973·The Journal of Pharmacy and Pharmacology·T R BatesE Dixon
Aug 1, 1997·Journal of Pharmaceutical and Biomedical Analysis·Y J WangJ K Lin
Feb 20, 1998·Japanese Journal of Pharmacology·S P Sinha BabuS Bhattacharya
Aug 21, 2001·Advances in Colloid and Interface Science·M A Bos, T van Vliet
Sep 3, 2002·International Journal of Pharmaceutics·Hanne Hjorth TønnesenThorsteinn Loftsson
Mar 21, 2006·BMC Complementary and Alternative Medicine·Christopher D LaoDean E Brenner
Sep 29, 2007·Biochemical Pharmacology·Ajay GoelBharat B Aggarwal
Oct 19, 2007·Critical Reviews in Food Science and Nutrition·David Julian McClements
Mar 8, 2008·Cellular and Molecular Life Sciences : CMLS·H HatcherS V Torti
Jan 20, 2009·Journal of Agricultural and Food Chemistry·Timothy H MarczyloAndreas J Gescher
Dec 15, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Banrida WahlangArvind K Bansal
Mar 6, 2012·Trends in Molecular Medicine·Liang Shen, Hong-Fang Ji
Dec 18, 2014·Cancer Biology & Therapy·Patricia Gomez-BougieMartine Amiot
Feb 3, 2015·Journal of Agricultural and Food Chemistry·Liqiang ZouDavid Julian McClements
Mar 31, 2015·Journal of Agricultural and Food Chemistry·Claus SchneiderPaula B Luis
May 15, 2008·Food Chemistry·Xiaoyong WangQingrong Huang
Jun 17, 2016·Current Pharmaceutical Design·Aditya P NayakIan Norton
Dec 10, 2016·Journal of Agricultural and Food Chemistry·Katherine Z SanidadGuodong Zhang
Dec 10, 2016·Journal of Agricultural and Food Chemistry·Mahesh KharatDavid Julian McClements
Jun 10, 2017·Seminars in Cancer Biology·David Julian McClements, Hang Xiao

❮ Previous
Next ❯

Citations

Jan 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan LiuMing-Wei Zhang
Jan 14, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Molet-RodríguezLaura Salvia-Trujillo
Sep 23, 2019·Journal of Colloid and Interface Science·Mahesh Kharat, David Julian McClements
Nov 17, 2019·Food Research International·Mahesh Kharat, David Julian McClements
Nov 13, 2020·Biotechnology Advances·Amaia Huguet-CasqueroJose Luis Pedraz
May 11, 2021·Journal of the Science of Food and Agriculture·Jose Antonio Vellido-PerezAntonio Martinez-Ferez
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Mahesh KharatDavid Julian McClements
Nov 9, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Zhiyang ChenJianguo Feng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.