Stability of flexible thin-film metallization stimulation electrodes: analysis of explants after first-in-human study and improvement of in vivo performance.

Journal of Neural Engineering
P. CvancaraT Stieglitz

Abstract

Micro-fabricated neural interfaces based on polyimide (PI) are achieving increasing importance in translational research. The ability to produce well-defined micro-structures with properties that include chemical inertness, mechanical flexibility and low water uptake are key advantages for these devices. This paper reports the development of the transverse intrafascicular multichannel electrode (TIME) used to deliver intraneural sensory feedback to an upper-limb amputee in combination with a sensorized hand prosthesis. A failure mode analysis on the explanted devices was performed after a first-in-human study limited to 30 d. About 90% of the stimulation contact sites of the TIMEs maintained electrical functionality and stability during the full implant period. However, optical analysis post-explantation revealed that 62.5% of the stimulation contacts showed signs of delamination at the metallization-PI interface. Such damage likely occurred due to handling during explantation and subsequent analysis, since a significant change in impedance was not observed in vivo. Nevertheless, whereas device integrity is mandatory for long-term functionality in chronic implantation, measures to increase the bonding strength of the metallizat...Continue Reading

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Citations

Mar 23, 2021·Journal of Neural Engineering·Valentina PaggiStéphanie P Lacour
May 4, 2021·Frontiers in Bioengineering and Biotechnology·Alejandro Carnicer-LombarteDamiano G Barone
Oct 28, 2020·Journal of Neural Engineering·Ivo StraussSilvestro Micera
Jun 2, 2021·Nature Biomedical Engineering·Dario FarinaOskar C Aszmann
May 22, 2021·Acta Biomaterialia·Poppy Oldroyd, George G Malliaras
Jul 31, 2021·Journal of Neural Engineering·Kristin K SellersEdward F Chang
Oct 28, 2021·Science Translational Medicine·Marion BadiSilvestro Micera

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